Protein/peptide-templated biomimetic synthesis of inorganic nanoparticles for biomedical applications
Protein/peptide-templated biomimetic synthesis of inorganic nanoparticles for biomedical applications
复制标题
用于生物医学应用的无机纳米颗粒的蛋白质/肽模板仿生合成
DOI：
10.1039/c6tb02308h
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发表时间：
2017
影响因子：
7
通讯作者：
Zhang Bingbo
中科院分区：
文献类型：
--
作者：
Yang Weitao;Guo Weisheng;Chang Jin;Zhang Bingbo
目前，基于蛋白质/肽的仿生矿化已被证明是一种有效的和有前途的策略，用于合成无机/金属纳米粒子（NPs）的生物应用。这种策略被发现是生物启发的，直接的，对环境无害的。它可以产生具有良好稳定性、优异的生物相容性、高水溶性和丰富的表面官能团的无机/金属NPs，用于进一步的生物结合。本文综述了近年来在仿生矿化合成中作为生物模板的蛋白质/肽类纳米粒子的研究进展，并对金属纳米团簇、量子点、钆衍生物、金属硫化物纳米粒子等无机纳米粒子进行了分类，重点介绍了它们在生物传感、离子检测、生物标记、体内成像和治疗。最后，对这一新兴领域面临的挑战和未来的展望进行了讨论。
Currently, protein/peptide-based biomimetic mineralization has been demonstrated to be an efficient and promising strategy for synthesis of inorganic/metal nanoparticles (NPs) for bioapplications. This strategy is found to be bio-inspired, straightforward, and environmentally benign. It can produce inorganic/metal NPs with good stability, excellent biocompatibility, high water solubility, and rich surface functional groups for further bioconjunction. In this review, we provide a summary of the previously reported proteins/peptides as biotemplates involved in biomimetic mineralization synthesis, and categorize the obtained inorganic NPs ranging from metal nanoclusters (MNCs), quantum dots (QDs), gadolinium derivatives, and metal sulfide nanoparticles (MSNPs) with an emphasis on the recent progress in their use in biomedical applications, including bio-sensing, ion detection, bio-labeling, in vivo imaging and therapy. In the end, the challenges and future outlook in this emerging area are also discussed.