Airway hysteresis in normal subjects and individuals with chronic airflow obstruction.
Airway hysteresis in normal subjects and individuals with chronic airflow obstruction.
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正常受试者和患有慢性气流阻塞的个体的气道滞后。
DOI：
10.1152/jappl.1985.58.5.1505
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Fairshter,RD
中科院分区：
文献类型：
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作者：
Fairshter,RD
在正常受试者和慢性气流阻塞 (CAO) 个体中，在总肺活量 (TLC) 容量历史之前和之后 5-10 秒，在没有预先药物诱导支气管收缩的情况下测量比电导 (sGaw)； TLC 吸气后 sGaw 增加被认为是气道滞后的证据。还在TLC吸气之前和之后测量了肺弹性反冲力[Pst(L)]。正常受试者中1）吸入TLC后支气管扩张剂前sGaw显着升高，而Pst(L)显着降低； 2) 环氧合酶活性调节剂对 sGaw 对深吸气的反应没有显着影响； 3) 吸入阿托品或异丙肾上腺素后气道迟滞现象减弱。在 CAO 组中，1）吸入 TLC 后支气管扩张剂前 sGaw 和 Pst（L）显着降低，2）吸入阿托品或异丙肾上腺素后深吸气后支气管收缩减少。这项研究表明，即使静息气道张力没有改变，正常气道也会表现出迟滞性，并且 CAO 中气道迟滞性受到损害。
Specific conductance (sGaw) was measured without prior pharmacological induction of bronchoconstriction before and 5–10 s after a total lung capacity (TLC) volume history in normal subjects and in individuals with chronic airflow obstruction (CAO); increased sGaw after inspiration to TLC was considered evidence of airway hysteresis. Lung elastic recoil [Pst(L)] was also measured before and after inspiration to TLC. In the normal subjects 1) prebronchodilator sGaw increased significantly, whereas Pst(L) decreased significantly after inspiration to TLC; 2) modulators of cyclooxygenase activity had no significant effects on sGaw responses to deep inspiration; and 3) airway hysteresis diminished after inhalation of atropine or metaproterenol. In the CAO group 1) prebronchodilator sGaw and Pst(L) decreased significantly after inspiration to TLC, and 2) bronchoconstriction after deep inspiration diminished after inhalation of atropine or metaproterenol. This study demonstrates that normal airways exhibit hysteresis even without alteration of resting airway tone and that airway hysteresis is impaired in CAO.