Improved microbial gene identification with GLIMMER
Improved microbial gene identification with GLIMMER
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DOI：
10.1093/nar/27.23.4636
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发表时间：
1999-12-01
影响因子：
14.9
通讯作者：
Salzberg, SL
中科院分区：
文献类型：
--
作者：
Delcher, AL;Harmon, D;Salzberg, SL
与已发表的注释相比，用于微生物基因鉴定的GIMMER系统发现与基因组中所有基因的97-98%相似。本文报告了两个新的结果：(1)对GLIMER进行了重大的技术改进，进一步提高了它的精度；(2)综合评价表明，该系统的精度可能比以前认识到的更高。该系统遗漏的很大一部分基因似乎是假想的蛋白质，其存在只有通过其他计划的预测才能得到支持。当分析局限于与其他生物体中的基因有显著同源性的基因时，Gimmer遗漏了
The GLIMMER system for microbial gene identification finds similar to 97-98% of all genes in a genome when compared with published annotation. This paper reports on two new results: (i) significant technical improvements to GLIMMER that improve its accuracy still further, and (ii) a comprehensive evaluation that demonstrates that the accuracy of the system is likely to be higher than previously recognized. A significant proportion of the genes missed by the system appear to be hypothetical proteins whose existence is only supported by the predictions of other programs. When the analysis is restricted to genes that have significant homology to genes in other organisms, GLIMMER misses