Iterative C-H Functionalization Leading to Multiple Amidations of Anilides
Iterative C-H Functionalization Leading to Multiple Amidations of Anilides
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DOI：
10.1002/anie.201701138
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发表时间：
2017-04-03
影响因子：
16.6
通讯作者：
Chang, Sukbok
中科院分区：
文献类型：
--
作者：
Park, Juhyeon;Lee, Jia;Chang, Sukbok
以二恶唑酮为氨基源，经季铵盐催化的苯胺重复C-H酰胺化反应合成了多氨基苯。这种策略可以通过新安装的酰胺基团的级联螯合辅助来顺序激活先前生成的化合物的C-H键来实现。计算研究提供了一个理由。
Polyaminobenzenes were synthesized by the ruthenium-catalyzed iterative C-H amidation of anilides using dioxazolones as an amino source. This strategy could be implemented by the sequential activation of C-H bonds of formerly generated compounds by cascade chelation assistance of newly installed amide groups. Computational studies provided a rationale.