Feasibility of replacing antibiotic feed promoters with the Chinese traditional herbal medicine Bazhen in weaned piglets
Feasibility of replacing antibiotic feed promoters with the Chinese traditional herbal medicine Bazhen in weaned piglets
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DOI：
10.1016/j.livsci.2006.09.008
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发表时间：
2007-04-01
影响因子：
1.8
通讯作者：
Wu, C. P.
中科院分区：
文献类型：
--
作者：
Lien, T. F.;Homg, Y. M.;Wu, C. P.
本研究探讨了用中草药八珍替代抗生素作为断奶仔猪生长促进剂的可行性。本研究使用了 36 头断奶仔猪（平均初始体重 8.92 +/- 1.18 kg）。根据体重、性别和窝产仔猪进行分组，然后随机分为对照组（基础日粮）、抗生素组（100 ppm 金霉素和 100 ppm 土霉素）和八珍组（1%），每组 3 栏。在为期 8 周的研究期间，仔猪可以自由获取水和饲料。实验结果表明，八珍组平均日增重高于对照组，但低于抗生素组。然而，与对照组和抗生素组相比，八珍组采食量减少，料重比提高。八珍组中性粒细胞活性和IgG水平高于对照组。八珍组在大肠杆菌脂多糖攻击后白细胞计数的增加高于对照组和抗生素组。此外，八珍组的IL-6和TNF-α（肿瘤坏死因子-α）水平高于抗生素组。八珍组的红细胞和丙种球蛋白水平分别高于抗生素组和对照组。另一方面，抗生素组显示出最高的 SRBC（羊红细胞）抗体滴度，并且与对照组存在显着差异。断奶时，补充八珍组仔猪的一些免疫反应，如白细胞和红细胞、IL-6 和 TNF-α 水平高于抗生素组。因此，八珍可能成为断奶仔猪饲料中抗生素（金霉素和土霉素）的潜在替代品。 (c) 2006 Elsevier B.V. 保留所有权利。
This study investigated the feasibility of replacing antibiotic as growth promoter for weaned piglets with the Chinese traditional herbal medicine Bazhen. Thirty-six weaned piglets (average initial body weight 8.92 +/- 1.18 kg) were used in this study. Pigs were blocked according to weight, sex and litter origin, and then randomly assigned to control (basal diet), antibiotics (100 ppm chlortetracycline and 100 ppm oxytetracycline) and Bazhen (1%) groups, with three pens per group. Piglets had free access to water and feed during this 8-week study period. Experimental results indicated that average daily gain of the Bazhen group was higher than that of the control group, but lower than that of the antibiotics group. However, feed intake was reduced while feed to gain ratio was improved in the Bazhen group compared to the control and antibiotics groups. The Bazhen group showed higher neutrophil activity and IgG levels than the control group. The increase in white blood cell counts of the Bazhen group when challenged with Escherichia coli lipopolysaccharide was higher than that in the control and antibiotics groups. Moreover, IL-6 and TNF-alpha (tumor necrosis factor-alpha) levels were higher in the Bazhen group than in the antibiotics group. Red blood cells and gamma-globulin levels were higher in the Bazhen group than in the antibiotics group and in the control group, respectively. On the other hand, the antibiotics group displayed the highest amount of SRBC (sheep red blood cell) antibody titers, and differed significantly from the control group. Some immune responses such as white and red blood cells, IL-6 and TNF-alpha levels were greater at weaning in the piglets of the Bazhen supplemented group than in those of the antibiotics group. Thus, Bazhen could be a potential substitute for antibiotics (chlorotetracycline and oxytetracycline) in weaned piglets feed. (c) 2006 Elsevier B.V. All rights reserved.