The role of eosinophils in the pathogenesis of asthma
The role of eosinophils in the pathogenesis of asthma
复制标题
DOI：
10.1016/j.molmed.2005.02.002
复制
发表时间：
2005-04-01
影响因子：
13.6
通讯作者：
Kay, AB
中科院分区：
文献类型：
--
作者：
Kay, AB
最近的两篇论文讨论了嗜酸性粒细胞在哮喘中的作用这一令人感兴趣的问题。两个研究组都使用了小鼠气道炎症的实验模型，这些模型是基因靶向的，以选择性地消除嗜酸性粒细胞谱系。一个研究小组发现嗜酸性粒细胞是气道高反应性和粘液积聚所必需的。另一个证明了细胞在气道重塑中的“关键作用”。这些结果虽然在很大程度上证实了以前在小鼠和人类中的研究，但将嗜酸性粒细胞坚定地置于哮喘阶段，并加强了开发有效的嗜酸性粒细胞消耗剂用于临床的情况。
Two recent papers have addressed the ever-intriguing question of the role of eosinophils; in asthma. Both groups used experimental models of airway inflammation in mice that were gene targeted to selectively ablate the eosinophil lineage. One group found that eosinophils were required for both airway hyperresponsiveness; and mucus accumulation. The other demonstrated a 'critical role'for the cell in airway remodelling. The results, although largely confirmatory of previous studies both in mice and humans, put the eosinophil firmly back on the asthma stage and strengthen the case for developing effective eosinophil-depleting agents for clinical use.