MICROPROBE ANALYSIS OF HUMAN OTOCONIA
MICROPROBE ANALYSIS OF HUMAN OTOCONIA
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DOI：
10.3109/00016488409130990
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发表时间：
1984-01-01
影响因子：
1.4
通讯作者：
WROBLEWSKI, R
中科院分区：
文献类型：
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作者：
ANNIKO, M;YLIKOSKI, J;WROBLEWSKI, R
1例胎儿（孕39周; 18三体）、2例婴儿（1 1/2和2个月）的椭圆形和囊状耳圆锥体（N = 510）3名成人（58岁、61岁和77岁）用能量色散X射线微探针分析。在所有耳石的元素组成显示出极高浓度的钙，但也确定钠，镁，磷，硫，氯和钾。非钙元素的存在被解释为是由于蛋白质核的耳石。非钙元素在胎龄和出生后早期比以后的生活中更突出。老年耳石含有高浓度的P，这表明老年耳石发生磷酸化，即，方解石耳石通过与磷酸根离子反应原位转化为磷灰石。18三体耳石的元素组成与生后早期内耳相似。
Utricular and saccular otoconia (N = 510) from 1 fetus (39th gestational week; trisomy-18), 2 babies (1 1/2 and 2 mo.) and 3 adults (58, 61 and 77 yr) were analyzed with an energy dispersive X-ray microprobe. In all otoconia the elemental composition showed an extremely high concentration of Ca, but also Na, Mg, P, S, Cl and K were identified. The presence of non-Ca elements was interpreted as being due to a protein nucleus of the otoconia. Non-Ca elements are more prominent during fetal age and early postnatally than later in life. Old age otoconia contained high concentrations of P which indicates that a phosphatization of aging otoconia occurs, i.e., calcite otoconia are transformed in situ into apatite by reaction with phosphate ions. The elemental composition of otoconia in Trisomy-18 was similar to that in early postnatal inner ears.