1991 VOLVO AWARD IN CLINICAL SCIENCES - SMOKING AND LUMBAR INTERVERTEBRAL-DISK DEGENERATION - AN MRI STUDY OF IDENTICAL-TWINS
1991 VOLVO AWARD IN CLINICAL SCIENCES - SMOKING AND LUMBAR INTERVERTEBRAL-DISK DEGENERATION - AN MRI STUDY OF IDENTICAL-TWINS
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DOI：
10.1097/00007632-199109000-00001
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发表时间：
1991-09-01
期刊：
影响因子：
3
通讯作者：
KOSKENVUO, M
中科院分区：
文献类型：
--
作者：
BATTIE, MC;VIDEMAN, T;KOSKENVUO, M
这项研究的主要目的是确定通过磁共振成像评估的腰椎间盘退变在吸烟者中是否比不吸烟者更严重。为了控制潜在混杂变量的最大数量，选择了吸烟程度高度不一致的同卵双胞胎作为研究对象。数据分析显示，与非吸烟者相比，吸烟者腰椎退变评分平均高出18%。这种影响存在于整个腰椎，暗示着一种全身作用的机制。这项调查证明了在研究多因素病因学的条件，如椎间盘退变时，使用精心挑选的对照是有效的。
The primary objective of this study was to determine whether disc degeneration, as assessed through magnetic resonance imaging, is greater in smokers than in nonsmokers. To control for the maximum number of potentially confounding variables, pairs of identical twins highly discordant for cigarette smoking were selected as study subjects. Data analyses revealed 18% greater mean disc degeneration scores in the lumbar spines of smokers as compared with nonsmokers. The effect was present across the entire lumbar spine, implicating a mechanism acting systemically. This investigation demonstrates the efficiency of using carefully selected controls in studying conditions of multifactorial etiology, such as disc degeneration.