Safety of post-exposure rabies prophylaxis during pregnancy A follow-up study from Guangzhou, China
Safety of post-exposure rabies prophylaxis during pregnancy A follow-up study from Guangzhou, China
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DOI：
10.4161/hv.22377
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发表时间：
2013-01-01
影响因子：
4.8
通讯作者：
Fu, Chuanxi
中科院分区：
文献类型：
--
作者：
Huang, Guihua;Liu, Huazhang;Fu, Chuanxi
本研究旨在评估孕妇暴露后预防（PEP）狂犬病的安全性。所有受试者均接受了埃森疫苗接种方案。在免疫后72小时内监测全身和局部反应，并随访受试者至分娩后6个月。接种疫苗后，任何受试者均未发生中度或重度不良反应。在该随访研究的72例受试者中，4例自愿流产，1例意外流产，其余67例经阴道或剖腹产分娩。所有的婴儿都表现出正常的发育。纯化的Vero细胞狂犬病疫苗和纯化的鸡胚细胞疫苗对孕妇的PEP都是安全的，并且不会干扰胎儿或婴儿的发育。在中国，由于担心狂犬病疫苗接种风险，需要进行教育以阻止妊娠终止。
This study aimed to assess the safety profile of post-exposure prophylaxis (PEP) for rabies in pregnant women. All of the subjects received the Essen vaccination regimen. Systemic and local reactions were monitored within 72 h following the immunization, and the subjects were followed until six months after delivery. No moderate or severe adverse effects occurred in any subject following the vaccination. Among the 72 subjects in this follow-up study, four had voluntary abortions, one subject had an accidental miscarriage, and the remaining 67 subjects delivered babies vaginally or by caesarean section. All of the infants exhibited normal development. The purified Vero cell rabies vaccine and the purified chick embryo cell vaccine were both safe for the PEP of pregnant women and did not interfere with the development of the fetuses or infants. Education is needed in China to stop pregnancy terminations due to concerns about rabies vaccination risk.