EFFECT OF POLYMORPHISM OF AN MHC-LINKED TRANSPORTER ON THE PEPTIDES ASSEMBLED IN A CLASS-I MOLECULE
EFFECT OF POLYMORPHISM OF AN MHC-LINKED TRANSPORTER ON THE PEPTIDES ASSEMBLED IN A CLASS-I MOLECULE
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DOI：
10.1038/357211a0
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发表时间：
1992-05-21
期刊：
影响因子：
64.8
通讯作者：
HOWARD, JC
中科院分区：
文献类型：
--
作者：
POWIS, SJ;DEVERSON, EV;HOWARD, JC
结合在I类主要组织相容性复合物分子沟中的短抗原肽使T细胞能够检测细胞内病原体。已经假设I类分子的结构特征单独选择结合哪些肽。现在证明，一个复杂的多态性在一个主要组织相容性复合体编码的推定肽转运蛋白基因与改变光谱的结合肽。
Short antigenic peptides bound in the groove of class I major histocompatibility complex molecules enable T cells to detect intracellular pathogens. It has been assumed that structural features of the class I molecule alone select which peptides are bound. It is now demonstrated that a complex polymorphism in one of the major histocompatibility complex-encoded putative peptide-transporter genes is associated with an altered spectrum of bound peptides.