OPT-80 Eliminates Clostridium difficile and Is Sparing of Bacteroides Species during Treatment of C-difficile Infection
OPT-80 Eliminates Clostridium difficile and Is Sparing of Bacteroides Species during Treatment of C-difficile Infection
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DOI：
10.1128/aac.01443-07
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发表时间：
2009-01-01
影响因子：
4.9
通讯作者：
Mah, Manuel
中科院分区：
文献类型：
--
作者：
Louie, Thomas J.;Emery, Judy;Mah, Manuel
在艰难梭菌感染的10天治疗中，OPT-80和万古霉素在减少艰难梭菌数量方面具有相似的效果。随着OPT-80剂量的增加，脆弱类杆菌的数量没有受到影响，而万古霉素则明显受到抑制。保留正常菌群的成分可能会降低复发的风险。
During a 10-day treatment for Clostridium difficile infection, OPT-80 and vancomycin were comparably effective in reducing C. difficile counts. Bacteroides fragilis group counts appeared unaffected with increasing dosages of OPT-80, whereas vancomycin was markedly suppressive. Retention of components of the normal microflora might lower the risk of recurrent disease.