Sacral nerve stimulation for the treatment of fecal incontinence.
Sacral nerve stimulation for the treatment of fecal incontinence.
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DOI：
10.1055/s-2005-864079
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发表时间：
2005-02-01
影响因子：
1.4
通讯作者：
Margolin, David A
中科院分区：
文献类型：
--
作者：
Brill, Scott A;Margolin, David A
对于完整但功能缺陷的括约肌和盆底肌肉系统，以及一些括约肌损伤，使用骶神经刺激作为大便失禁的治疗方法是一个有吸引力的概念，目前正在美国进行临床试验。在骶脊神经水平电刺激周围神经供应到横纹肛门括约肌，利用双重周围神经供应到这些肌肉的最远端共同位置的可达性。尽管目前关于骶神经刺激的有益作用的机制仍然是猜测的，可能是多因素的，但目前的实验数据表明，横纹肌活动的增强以及调节直肠敏感性和收缩能力的骶骨反射的神经调节。
The use of sacral nerve stimulation as a treatment for fecal incontinence for intact but functionally deficient sphincter and pelvic floor musculature, as well as for some sphincter injuries, is an attractive concept that is currently undergoing clinical trials in the United States. Electrical stimulation of the peripheral nerve supply to the striated anal sphincter muscles at the level of the sacral spinal nerves exploits the accessibility of the most distal common location of the dual peripheral nerve supply to these muscles. While the mechanism of sacral nerve stimulation's salutary effect remains conjectural at present and is likely multifactorial, current experimental data point toward both an enhancement in striated muscular activity as well as neuromodulation of sacral reflexes that regulate rectal sensitivity and contractility.