CONTROL OF BLOOD-PRESSURE IN LONG SLOW HEMODIALYSIS
CONTROL OF BLOOD-PRESSURE IN LONG SLOW HEMODIALYSIS
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DOI：
10.1159/000170171
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发表时间：
1994-07-01
影响因子：
3
通讯作者：
CHARRA, B
中科院分区：
文献类型：
--
作者：
CHARRA, B
高血压是血液透析患者死亡和发病的主要原因。对692例患者进行长期缓慢透析(8h/次)。它可以很好地控制血压，而不需要抗高血压药物。在透析前平均动脉压较低的患者亚组中，心血管发病率和死亡率较低。对细胞外容量的控制和较低的透析内低血压发生率是对这一结果的最可能的解释。另一种可能的机制是通过大剂量的透析恢复被尿毒症患者血清中二甲基精氨酸积聚所抑制的一氧化氮血管扩张作用。
Hypertension is a major cause of mortality and morbidity in hemodialysis patients. A long slow dialysis (8 h/session) was used in 692 unselected patients. It allowed for an excellent control of blood pressure without the need of antihypertensive medications. Cardiovascular morbidity and mortality were lower in the subgroups of patients presenting with a lower predialysis mean arterial pressure. The control of the extracellular volume with a low rate of intradialytic hypotensive episodes is the most probable explanation of this result. Another possible mechanism is the restoration by the large dose of dialysis of the nitric oxide vasodilator action inhibited by the accumulation of dimethylarginine in the serum of uremic patients.