Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity.
Brief survey on organometalated antibacterial drugs and metal-based materials with antibacterial activity.
复制标题
有机抗菌药物及金属基抗菌材料的研究概况。
DOI：
10.1039/d0cb00218f
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发表时间：
2021-04-01
影响因子：
4.1
通讯作者：
Kowalski K
中科院分区：
文献类型：
--
作者：
Biegański P;Szczupak Ł;Arruebo M;Kowalski K
细菌抗生素耐药性上升是一个全球性威胁。为了解决这一问题，需要开发新的抗菌剂和防腐材料。在这方面的一个替代方案是完善的抗菌药物的有机金属衍生化，以及具有抗菌性能的先进金属基材料的制造。基于金属的试剂和材料通常显示出新的抗菌作用模式，使它们能够克服病原菌菌株的耐药性。本文综述了近年来（2017-2020年）有机金属抗菌药物和具有抗菌活性的金属基材料的研究进展。具体而言，它涵盖了抗菌药物的有机金属衍生物，包括β-内酰胺、环丙沙星、异烟肼、甲氧苄啶、磺胺甲恶唑、乙胺丁醇以及非抗菌药物，如二甲双胍、苯乙双胍和阿司匹林。最新进展和报告的临床试验中使用的金属基纳米材料作为抗生物污损涂层的医疗设备，作为光催化剂在室内空气污染物控制，也作为光动力/光热抗菌剂进行了总结。综述了近年来有机抗菌药物和具有抗菌活性的金属基材料的研究进展。它们成为对抗病原菌包括耐药菌株的有吸引力的候选物。
Rising bacterial antibiotic resistance is a global threat. To deal with it, new antibacterial agents and antiseptic materials need to be developed. One alternative in this quest is the organometallic derivatization of well-established antibacterial drugs and also the fabrication of advanced metal-based materials having antibacterial properties. Metal-based agents and materials often show new modes of antimicrobial action which enable them to overcome drug resistance in pathogenic bacterial strains. This review summarizes recent (2017–2020) progress in the field of organometallic-derived antibacterial drugs and metal-based materials having antibacterial activity. Specifically, it covers organometallic derivatives of antibacterial drugs including β-lactams, ciprofloxacin, isoniazid, trimethoprim, sulfadoxine, sulfamethoxazole, and ethambutol as well as non-antibacterial drugs like metformin, phenformin and aspirin. Recent advances and reported clinical trials in the use of metal-based nanomaterials as antibiofouling coatings on medical devices, as photocatalytic agents in indoor air pollutant control, and also as photodynamic/photothermal antimicrobial agents are also summarized. Recent developments in the field of organometalated antibacterial drugs and metal-based materials with antibacterial activity are reviewed. They emerge as attractive candidates for combating pathogenic bacteria including drug resistant strains.