Mechanisms of resistance to PARP inhibitors--three and counting.
Mechanisms of resistance to PARP inhibitors--three and counting.
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DOI：
10.1158/2159-8290.cd-12-0514
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发表时间：
2013-01
期刊：
影响因子：
28.2
通讯作者：
Bates S
中科院分区：
文献类型：
--
作者：
Fojo T;Bates S
考虑到癌细胞的可塑性，我们应该预料到，并且确实看到，对任何新的化疗药物的耐药性的发展。帮助我们了解这种情况如何发生的模型是更好，更有效的化疗的第一步。
Given the malleable nature of cancer cells, we should expect, and do see, the development of resistance to any new chemotherapeutic agent. Models that help us understand how this happens are a first step to better and more effective chemotherapeutics.