Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals
Elevated circulating cathepsin S levels are associated with metabolic syndrome in overweight and obese individuals
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DOI：
10.1002/dmrr.3117
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发表时间：
2019-03-01
影响因子：
8
通讯作者：
Hu, Renming
中科院分区：
文献类型：
--
作者：
Chen, Lili;Bin, Lu;Hu, Renming
目的组织蛋白酶S（Cathepsin S）在皮下和内脏脂肪组织中高表达。组织蛋白酶S与中心性肥胖相关，并促进动脉粥样硬化的形成和进展。在此，我们试图评估超重和肥胖的中国成年人血清组织蛋白酶S与代谢综合征（MS）的关系。方法采用酶联免疫吸附试验（ELISA）检测781例超重和肥胖成人血清组织蛋白酶S水平。还测量了葡萄糖、胰岛素、血脂、炎症标志物和脂肪因子。结果组织蛋白酶S与BMI、腰围、腰臀比、空腹血糖、空腹胰岛素、胰岛素抵抗指数（HOMA-IR）、收缩压、C反应蛋白（CRP）、甘油三酯、高密度脂蛋白胆固醇（HDL）显著相关（P均< 0.05）。校正潜在混杂因素后，随着MS组分数量的增加，血浆组织蛋白酶S水平显著升高（趋势P = 0.045）。在校正年龄、性别、饮酒、吸烟、教育、体力活动、自报CVD和糖尿病家族史后，组织蛋白酶S最高四分位数的MS风险显著高于最低四分位数（比值比2.30; 95%置信区间1.89-2.78）。在进一步控制CRP、脂联素、HOMA-IR和BMI后，这种关联仍然很强（比值比1.97; 95%置信区间1.72-2.48）。结论在超重和肥胖的中国成年人中，循环中组织蛋白酶S浓度升高与MS密切相关。需要前瞻性研究来确定组织蛋白酶S在MS发展中的作用。
Objective Cathepsin S is highly expressed in subcutaneous and visceral adipose tissue. Cathepsin S correlates with central obesity and contributes to the formation and progression of atherosclerosis. Here, we sought to evaluate the association of serum cathepsin S with metabolic syndrome (MS) in overweight and obese Chinese adults. Methods We evaluated serum cathepsin S levels in a cross-sectional sample of 781 overweight and obese Chinese adults by ELISA. Glucose, insulin, lipid profile, inflammatory markers, and adipokines were also measured. Results Cathepsin S was significantly associated with BMI, waist circumference, waist-to-hip ratio, fasting glucose, fasting insulin, the homeostatic model assessment of insulin resistance (HOMA-IR), systolic blood pressure, C-reactive protein (CRP), triglycerides, and HDL cholesterol (all P < 0.05). Plasma cathepsin S levels increased significantly (P = 0.045 for trend) with increasing numbers of MS components after adjustment for potential confounders. In the highest cathepsin S quartile, the MS risk was significantly higher (odds ratio 2.30; 95% confidence interval, 1.89-2.78) than in the lowest quartile after adjustment for age, gender, alcohol consumption, smoking, education, physical activity, self-reported CVD, and family history of diabetes. This association remained strong (odds ratio 1.97; 95% confidence interval, 1.72-2.48) after controlling further for CRP, adiponectin, HOMA-IR, and BMI. Conclusions Elevated circulating cathepsin S concentrations are strongly and independently associated with MS in overweight and obese Chinese adults. Prospective studies are needed to establish the role of cathepsin S in the development of MS.