Single-motor mechanics and models of the myosin motor
Single-motor mechanics and models of the myosin motor
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DOI：
10.1098/rstb.2000.0585
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发表时间：
2000-04-29
期刊：
影响因子：
--
通讯作者：
Tokunaga, M
中科院分区：
文献类型：
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作者：
Yanagida, T;Esaki, S;Tokunaga, M
单分子检测技术的最新进展是显著的。这些技术已经允许准确测定肌球蛋白头诱导的位移和机械周期如何耦合到ATP水解，通过直接在单分子水平上测量肌动球蛋白的单个机械事件和化学事件。在这里，我们回顾了我们最近的工作中，我们已经取得了详细的测量肌球蛋白步长和机械化学耦合，并提出了一个模型的肌球蛋白马达。
Recent progress in single-molecule detection techniques is remarkable. These techniques have allowed the accurate determination of myosin-head-induced displacements and how mechanical cycles are coupled to ATP hydrolysis, by measuring individual mechanical events and chemical events of actomyosin directly at the single-molecule level. Here we review our recent work in which we have made detailed measurements of myosin step size and mechanochemical coupling, and propose a model of the myosin motor.