Metabolic adaptations after bariatric surgery: adipokines, myokines and hepatokines
Metabolic adaptations after bariatric surgery: adipokines, myokines and hepatokines
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DOI：
10.1016/j.coph.2020.06.005
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发表时间：
2020-06-01
影响因子：
4
通讯作者：
Tchernof, Andre
中科院分区：
文献类型：
--
作者：
Faramia, Justine;Ostinelli, Giada;Tchernof, Andre
本文综述了减肥手术对白色脂肪组织、肌肉和肝脏内分泌方面的影响。我们描述了支持脂肪因子、肌因子和肝因子可能协同作用并在手术后驱动许多长期代谢改善的观点的文献。循环脂联素增加，而促炎性白细胞介素（1、6和8）的分泌减少，同时瘦素分泌减少。在肌肉中观察到的代谢改善可能与导致胰岛素抵抗的肌因子（包括肌生长抑制素、脑源性神经营养因子和成纤维细胞生长因子-21）减少有关。除例外情况外，肝细胞因子分泌通常增加（如胰岛素样生长因子结合蛋白2、肾上腺素和性激素结合球蛋白）。总之，减肥手术通过增强抗炎、胰岛素增敏和降血脂因子的时间依赖性分泌来恢复代谢功能。需要进一步的研究来了解这些因素可能触发减肥手术后肥胖相关合并症缓解的分子机制。
This review addresses the impact of bariatric surgery on the endocrine aspects of white adipose tissue, muscle and the liver. We describe literature supporting the notion that adipokines, myokines and hepatokines likely act in concert and drive many of the long-term metabolic improvements following surgery. Circulating adiponectin is increased while secretion of pro-inflammatory interleukins (1, 6 and 8) decreases, alongside leptin secretion. The metabolic improvements observed in the muscle might relate to reduction of myokines contributing to insulin resistance (including myostatin, brain-derived neurotrophic factor and fibroblast growth factor-21). Subject to exception, hepatokine secretion is generally increased (such as insulin-like growth factor-binding protein 2, adropin and sex hormone-binding globulin). In conclusion, bariatric surgery restores metabolic functions by enhancing the time-dependent secretion of anti-inflammatory, insulin-sensitizing and antilipemic factors. Further research is needed to understand the molecular mechanisms by which these factors may trigger the remission of obesity-related comorbidities following bariatric surgery.