The emerging roles of YAP and TAZ in cancer.
The emerging roles of YAP and TAZ in cancer.
复制标题
YAP和TAZ在癌症中的新兴作用。
DOI：
10.1038/nrc3876
复制
发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
Guan KL
中科院分区：
文献类型：
--
作者：
Moroishi T;Hansen CG;Guan KL
是细胞相关蛋白（雅普）和转录辅激活因子（TAZ）是Hippo通路的主要下游效应子，参与调节组织稳态、器官大小、再生和肿瘤发生。在这篇进展文章中，我们总结了目前对雅普和TAZ生物学功能的理解，以及这两种蛋白质的调节如何在癌症中被破坏。我们还强调了最近的研究结果，他们在癌症进展中的作用不断扩大，并描述了这些目标的治疗干预的潜力。
Yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ) are the major downstream effectors of the Hippo pathway, which regulates tissue homeostasis, organ size, regeneration and tumorigenesis. In this Progress article, we summarize the current understanding of the biological functions of YAP and TAZ, and how the regulation of these two proteins can be disrupted in cancer. We also highlight recent findings on their expanding role in cancer progression and describe the potential of these targets for therapeutic intervention.