Targeting Engineered Nanoparticles for Breast Cancer Therapy.
Targeting Engineered Nanoparticles for Breast Cancer Therapy.
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DOI：
10.3390/pharmaceutics13111829
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发表时间：
2021-11-01
期刊：
影响因子：
5.4
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Ganesan K;Wang Y;Gao F;Liu Q;Zhang C;Li P;Zhang J;Chen J
乳腺癌（BC）是全球女性中仅次于肺癌的第二大常见癌症。目前，治疗乳腺癌最重要的方法是手术，其次是放疗和化疗。后一种治疗方法在BC的治疗中通常是不成功的，因为它们的各种副作用和对健康组织和器官的损害。目前，已经鉴定和合成了许多纳米颗粒（NP），以选择性地靶向BC细胞，而不会对邻近的正常组织或器官造成任何损害。基于一项探索性研究，这一全面的审查旨在提供信息的工程纳米粒子及其有效载荷作为有前途的工具，在治疗BC。治疗药物或天然生物活性化合物通常掺入具有理想尺寸和形状的工程化NP，以增强其溶解度、循环半衰期和生物分布，同时降低其副作用和免疫原性。此外，NP表面上的配体如肽、抗体和核酸精确地靶向BC细胞。从PubMed、Science Direct和Google Scholar获得了关于工程化NP的合成及其对BC的影响的研究。这篇综述提供了关于工程化NP的重要性及其验证方法的见解，作为对BC具有预防和治疗作用的下一代平台。
Breast cancer (BC) is the second most common cancer in women globally after lung cancer. Presently, the most important approach for BC treatment consists of surgery, followed by radiotherapy and chemotherapy. The latter therapeutic methods are often unsuccessful in the treatment of BC because of their various side effects and the damage incurred to healthy tissues and organs. Currently, numerous nanoparticles (NPs) have been identified and synthesized to selectively target BC cells without causing any impairments to the adjacent normal tissues or organs. Based on an exploratory study, this comprehensive review aims to provide information on engineered NPs and their payloads as promising tools in the treatment of BC. Therapeutic drugs or natural bioactive compounds generally incorporate engineered NPs of ideal sizes and shapes to enhance their solubility, circulatory half-life, and biodistribution, while reducing their side effects and immunogenicity. Furthermore, ligands such as peptides, antibodies, and nucleic acids on the surface of NPs precisely target BC cells. Studies on the synthesis of engineered NPs and their impact on BC were obtained from PubMed, Science Direct, and Google Scholar. This review provides insights on the importance of engineered NPs and their methodology for validation as a next-generation platform with preventive and therapeutic effects against BC.
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影响因子：
10.8
作者：
Bhattacharya, Saurav;Ghosh, Avijit;Adhikary, Arghya
通讯作者：
Adhikary, Arghya
影响因子：
50.5
作者：
Chan, S;Davidson, N;Lee, LW
通讯作者：
Lee, LW
影响因子：
45.3
作者：
Bardia, Aditya;Mayer, Ingrid A.;Vahdat, Linda T.
通讯作者：
Vahdat, Linda T.
DOI：
10.1038/mt.2009.228
发表时间：
2010-02
期刊：
Molecular therapy : the journal of the American Society of Gene Therapy
影响因子：
--
作者：
通讯作者：
--
影响因子：
8
作者：
Alsagaby SA;Vijayakumar R;Premanathan M;Mickymaray S;Alturaiki W;Al-Baradie RS;AlGhamdi S;Aziz MA;Alhumaydhi FA;Alzahrani FA;Alwashmi AS;Al Abdulmonem W;Alharbi NK;Pepper C
通讯作者：
Pepper C