Systemic lupus erythematosus: a model for atherogenesis?
Systemic lupus erythematosus: a model for atherogenesis?
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系统性红斑狼疮：动脉粥样硬化模型？
DOI：
10.1093/rheumatology/39.4.353
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Manzi,S
中科院分区：
文献类型：
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作者：
Manzi,S
患有系统性红斑狼疮 (SLE) 的年轻女性会削弱女性的优势，包括家族性胆汁过多、冠心病、血红蛋白血症的发生率极高 [12] 和过早绝经 [13]。[1-4]。在我们能够解开为什么这些与早产年轻女性相关的较少公开的实体如此受苦之前，我们必须首先探索我们对冠心病（类风湿性关节炎）[14-16]的一般心血管疾病和系统性红斑狼疮[1-4]的了解。女性人口数量已得到充分证明。只有将我们对 SLE 的认识与 SLE 和动脉粥样硬化的过早心脏病风险相结合，并检查血管疾病（现在是死亡的主要原因之一，这两种疾病共同的危险因素），我们才能在这一人群中开始。揭示为什么这些疾病过程如此频繁地相互关联的复杂性。
Young women with systemic lupus erythematosus (SLE) lessen the female advantage include familial hypercholeshave strikingly high rates of coronary heart disease terolaemia [12] and premature menopause [13].[1–4]. Before we can solve the mystery of why these Less publicized entities associated with premature young women are so afflicted, we must first explore our coronary heart disease are rheumatoid arthritis [14–16] understanding of cardiovascular disease in the general and SLE [1–4]. It has been well proven that women population. Only by coupling our knowledge of the with SLE are at significant risk of premature cardiopathogenesis of SLE and atherosclerosis and examining vascular disease, now one of the leading causes of death the risk factors common to both diseases can we begin in this population. to unravel the complexity of why these disease processes are so frequently linked.