Analysis of Risk Factors for Organic Erectile Dysfunction in Egyptian Patients Under the Age of 40 Years
Analysis of Risk Factors for Organic Erectile Dysfunction in Egyptian Patients Under the Age of 40 Years
复制标题
DOI：
10.2164/jandrol.108.007195
复制
发表时间：
2009-09-01
影响因子：
--
通讯作者：
Salem, Khaled A.
中科院分区：
文献类型：
--
作者：
Elbendary, Mohamed A.;El-Gamal, Osama M.;Salem, Khaled A.
许多危险因素与勃起功能障碍 (ED) 的发病机制有关，但尚不清楚哪些因素与年轻人更相关。该项目的目的是寻找年轻患者患这种疾病的最重要的危险因素。我们纳入了 434 名年龄小于 40 岁的器质性 ED 患者和 272 名年龄匹配的对照者。所有参与者都采集了完整的病史（包括国际勃起功能指数-5 [IIEF-5]），并接受了体检和一些实验室检查。然后应用单变量分析研究以下因素在 ED 易感性中的重要性：吸烟、使用娱乐性药物、肥胖、血脂异常、糖尿病、高血压、冠心病和慢性盆腔疼痛综合征。该分析表明，吸烟、使用娱乐性药物、血脂异常、高血压和肥胖是显着因素（每个因素 P < .05）。当在多变量模型中研究这些重要因素时，维持统计显着性的唯一因素是吸烟（P < .05；比值比 [OR]，1.78；95% 置信区间 [95% CI]，1.16-2.72）和使用消遣性药物（P < .05；OR，3.18；95% CI，1.15-8.82）。此外，阳痿患者的吸烟指数与其 IIEF-5 评分呈负相关（r(2) = 0.67；P < .05）。总之，吸烟和使用消遣性药物是 40 岁以下患者发生器质性 ED 的最重要危险因素。
Many risk factors have been implicated in the pathogenesis of erectile dysfunction (ED), but it is not clearly evident which of these factors are more relevant among the young population. The aim of this project was to find the most significant risk factors for this disease in young patients. We included 434 patients with organic ED younger than 40 years and 272 age-matched controls. All participants had their complete history taken (including the International Index of Erectile Function-5 [IIEF-5]) and underwent physical examination and some laboratory investigations. Univariate analysis was then applied to study the significance of the following factors in the predisposition of ED: smoking, use of recreational drugs, obesity, dyslipidemia, diabetes mellitus, hypertension, coronary heart disease, and chronic pelvic pain syndrome. This analysis showed that smoking, use of recreational drugs, dyslipidemia, hypertension, and obesity were the significant factors (P < .05 for each factor). When these significant factors were studied in the multivariate model, the only factors that sustained the statistical significance were smoking (P < .05; odds ratio [OR], 1.78; 95% confidence interval [95% CI], 1.16-2.72) and use of recreational drugs (P < .05; OR, 3.18; 95% CI, 1.15-8.82). In addition, a negative correlation was detected between the smoking index of the impotent patients and their IIEF-5 score (r(2) = 0.67; P < .05). In conclusion, smoking and the use of recreational drugs are the most significant risk factors for organic ED in patients younger than 40 years.