Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms
Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms
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DOI：
10.1038/jhg.2010.82
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发表时间：
2010-10-01
影响因子：
3.5
通讯作者：
Inoue, Ituro
中科院分区：
文献类型：
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作者：
Akiyama, Koichi;Narita, Akira;Inoue, Ituro
颅内动脉瘤（IA）是一个主要的公共卫生问题，它导致蛛网膜下腔出血，破裂后死亡率高。为了确定IA的遗传易感性位点，我们在日本病例对照受试者中使用全基因组单核苷酸多态性（SNPs）进行了多阶段关联研究。在这项研究中，我们评估了标准方法中的关联证据，以及在遗传效应和疾病之间起作用的调整性别效应的额外测试。因此，5个SNP TMEM 195基因间区rs 1930095、rs 4628172、rs7781293、rs7550260、rs 4628172、rs7781293、rs7550260、rs7781293、rs7550260、rs7550263、rs IQSEC 1的rs 9864101的P-3.63 x 10（-5）），假阳性概率
An intracranial aneurysm (IA), which results in a subarachnoid hemorrhage with a high mortality on rupture, is a major public health concern. To identify genetic susceptibility loci for IA, we carried out a multistage association study using genome-wide single nucleotide polymorphisms (SNPs) in Japanese case-control subjects. In this study, we assessed evidence for association in standard approaches, and additional tests with adjusting sex effects that act between genetic effect and disease. Consequently, five SNPs (P=1.31 x 10(-5) for rs1930095 of intergenic region; P=1.32 x 10(-5) for rs4628172 of TMEM195; P-2.78 x 10(-5) for rs7781293 of TMEM195; P-4.93 x 10(-5) for rs7550260 of ARHGEF11; and P-3.63 x 10(-5) for rs9864101 of IQSEC1) with probabilities of being false positives