Programming the Curvatures in Reconfigurable DNA Domino Origami by Using Asymmetric Units
Programming the Curvatures in Reconfigurable DNA Domino Origami by Using Asymmetric Units
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DOI：
10.1021/acs.nanolett.0c03348
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发表时间：
2020-11-11
期刊：
影响因子：
10.8
通讯作者：
Ke, Yonggang
中科院分区：
文献类型：
--
作者：
Wang, Dongfang;Yu, Lei;Ke, Yonggang
DNA折纸技术是一种用于设计具有规定形状（包括复杂弯曲几何形状）的DNA纳米结构的稳健方法。除了静态结构，动态DNA折纸已被用于构建复杂的纳米机器，可以根据外部刺激重新配置其形状。在这里，我们报告了一种新的方法来设计DNA折纸结构，可以在非弯曲构象和弯曲构象之间转换。这种可重构结构是在动态DNA多米诺折纸的基础上发展起来的，它可以在触发DNA链启动的级联过程中进行变换。弯曲的程度可以通过调整折纸中DNA单元的大小来编程。
The DNA origami technique is a robust method for the design of DNA nanostructures with prescribed shapes, including complex curved geometries. In addition to static structures, dynamic DNA origami has been used to construct sophisticated nanomachines that can reconfigure their shapes in response to external stimuli. Here, we report a new method to design DNA origami structures that can transform between a noncurved conformation and curved conformation. The reconfigurable structures are developed on the basis of dynamic DNA domino origami, which can transform in a cascading process initiated by trigger DNA strands. The degree of curvature could be programmed by tuning the sizes of DNA units within the origami.