Acute stress shortens the time to onset of experimental allergic encephalomyelitis in SJL/J mice
Acute stress shortens the time to onset of experimental allergic encephalomyelitis in SJL/J mice
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DOI：
10.1016/s0889-1591(02)00028-4
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发表时间：
2002-12-01
影响因子：
15.1
通讯作者：
Theoharides, TC
中科院分区：
文献类型：
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作者：
Chandler, N;Jacobson, S;Theoharides, TC
实验性变态反应性脑脊髓炎(EAE)是多发性硬化症(MS)的小鼠模型，多发性硬化症(MS)是中枢神经系统(CNS)的一种炎症状态，由于致敏的T细胞通过血脑屏障(BBB)渗透，导致局灶性脱髓鞘。虽然慢性应激模型已被证明可以减少EAE，但急性情绪应激似乎会加剧许多神经炎性疾病。包括缓解-复发的MS，这是我们所知的唯一一项考察了急性应激对EAE影响的研究。SJL/J小鼠在接种蛋白脂蛋白(PLP)后的第2天和第3天制动60min，出现EAE症状的时间比对照组提前了4d。这种效应可能是由于血脑屏障通透性增加所致，通过使用伽马相机检测(99)Tc(TC-99)葡聚糖酸盐在应激后渗入脑实质的可能性。急性束缚应激60min后，血脑屏障通透性较对照组增加80%。这些发现可能有助于解释EAE症状较早出现的原因。(C)2002年埃尔塞维尔科学公司(美国)。版权所有。
Experimental allergic encephalomyelitis (EAE) is a murine model of multiple sclerosis (MS), an inflammatory condition of the central nervous system (CNS) resulting in focal demyelination due to the infiltration of sensitized T-leukocytes through the blood-brain barrier (BBB). While chronic stress models have been shown to reduce EAE, acute emotional stress appears to exacerbate many neuroinflammatory disorders. including remitting-relapsing MS. This is the only study to our knowledge that examined the effect of acute stress on EAE. Immobilization of SJL/J mice for 60 min, at days 2 and 3 post-inoculation with proteolipid protein (PLP), resulted in symptoms of EAE becoming apparent 4 days earlier than in control mice. The possibility that this effect could be due to increased BBB permeability was investigated by detecting (99)Technetium (Tc-99) gluceptate extravasation into brain parenchyma post-stress utilizing a gamma camera. There was 80% increase in BBB permeability after 60 min of acute immobilization stress as compared to controls. These findings may help explain the earlier onset of EAE symptoms. (C) 2002 Elsevier Science (USA). All rights reserved.