Respiratory-modulated and phrenic afferent-driven neurons in the cervical spinal cord (C4-C6) of the fluorocarbon-perfused guinea pig.
Respiratory-modulated and phrenic afferent-driven neurons in the cervical spinal cord (C4-C6) of the fluorocarbon-perfused guinea pig.
复制标题
氟碳灌注豚鼠颈脊髓 (C4-C6) 中的呼吸调节和膈传入驱动神经元。
DOI：
10.1007/bf00228399
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发表时间：
1993
影响因子：
2
通讯作者：
Getting,PA
中科院分区：
文献类型：
--
作者：
Cleland,CL;Getting,PA
通过细胞外记录氟碳灌注的成年豚鼠虚构呼吸期间C4-C6脊髓中神经元的活动模式，研究了颈脊髓中间神经元对呼吸神经控制的潜在贡献。记录了两种类型的神经元：呼吸调节神经元，其活动受呼吸调节，膈驱动神经元，其由膈神经的电刺激兴奋。呼吸调制神经元（n= 20）可以分为吸气，呼气，和相位跨越神经元，根据其活动模式在虚构的呼吸。呼吸调制的神经元表现出不同的依赖于呼吸的类型;在自发增强呼吸，一半表现出的活动模式，显着不同的正常，虚构的呼吸过程中看到的，而另一半的呼吸调制的神经元在正常和增强呼吸过程中表现出类似的活动模式。膈驱动神经元（n= 22）可分为短潜伏期（7-12 ms）、中潜伏期（12-25 ms）和抑制型神经元，但仅偶尔受到呼吸的微弱调制。这些结果表明，呼吸调节的C4-C6脊髓神经元可能有助于呼吸的神经控制，不同的亚群专门用于不同类型的呼吸任务，膈驱动的神经元可能会介入感觉或反射通路，如脊髓丘脑束或膈-膈抑制反射。
The potential contributions of cervical spinal interneurons to the neural control of respiration have been investigated by extracellularly recording the patterns of activity of neurons in the C4–C6 spinal cord during fictive respiration in the fluorocarbon-perfused, adult guinea pig. Two types of neurons were recorded:respiratory-modulatedneurons, whose activity was modulated with respiration, andphrenic-drivenneurons, which were excited by electrical stimulation of the phrenic nerve. Respiratory-modulated neurons (n= 20) could be divided into inspiratory, expiratory, and phase-spanning neurons, based on their patterns of activity during fictive respiration. Respiratory-modulated neurons showed varying dependencies on the type of breathing; during spontaneous augmented breaths, one-half exhibited patterns of activity that were significantly different to those seen during normal, fictive respiration, whereas the other half of the respiratory-modulated neurons showed similar patterns of activity during both normal and augmented breaths. Phrenic-driven neurons (n= 22) could be divided into short-latency (7–12 ms), moderate-latency (12–25 ms), and inhibited neurons, but were only occasionally and weakly modulated with respiration. The results suggest that respiratory-modulated C4–C6 spinal neurons may contribute to the neural control of respiration, with different subpopulations specialized for different types of respiratory tasks, and that phrenic-driven neurons may be interposed in sensory or reflex pathways, such as the spinothalamic tract or phrenic-to-phrenic inhibitory reflex.