Developmental characteristics in the daily rhythm of norepinephrine concentration within rabbit brainstem regions.
Developmental characteristics in the daily rhythm of norepinephrine concentration within rabbit brainstem regions.
复制标题
兔脑干区域去甲肾上腺素浓度日节律的发育特征。
DOI：
10.1071/rd9960189
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
McNamara,MC
中科院分区：
文献类型：
--
作者：
Gingras,JL;Lawson,EE;McNamara,MC
为了检查去甲肾上腺素水平的每日变化的发展，在3日龄、21日龄和成年兔的5个不同脑干区域内全天以6小时的间隔测量去甲肾上腺素浓度。通过放射酶测定法测量去甲肾上腺素，并将去甲肾上腺素浓度相对于湿组织重量表示。这些数据表明，去甲肾上腺素浓度的每日变化是由生命的第三天建立的。在脑干中，作为一个整体，有一个早期的夜间高峰（2130小时）为3日龄的动物，而晚夜间高峰（0330小时）为21日龄的动物。成年动物表现出一个昼夜晚（15 - 30小时）高峰。这些总的每日变化构成了去甲肾上腺素浓度每日变化发展中不同区域特异性模式的总和。去甲肾上腺素参与心肺调节和睡眠/觉醒周期的调节。所观察到的发育模式可能与这些生理过程的成熟和整合有关。
To examine the development of daily variations in norepinephrine levels, norepinephrine concentrations were measured within five distinct brainstem regions in 3-day-old, 21-day-old, and adult rabbits at 6-h intervals throughout the day. Norepinephrine was measured by radioenzymatic assay, and norepinephrine concentration was expressed relative to wet tissue weight. The data suggest that daily variations for norepinephrine concentrations are established by the third day of life. In the brainstem as a whole, there was an early nocturnal peak (2130 hours) for 3-day-old animals in contrast to a late nocturnal peak (0330 hours) for 21-day-old animals. Adult animals showed a late diurnal (1530 hours) peak. These gross daily variations constitute the sum of distinct region-specific patterns in the development of daily variations in norepinephrine concentration. Norepinephrine is involved in cardiorespiratory regulation and in the regulation of sleep/wake cycles. The observed developmental patterns may relate to the maturation and integration of these physiologic processes.