Sickle erythrocytes increase prostacyclin and endothelin-1 production by cultured human endothelial cells under flow conditions.
Sickle erythrocytes increase prostacyclin and endothelin-1 production by cultured human endothelial cells under flow conditions.
复制标题
镰状红细胞在流动条件下增加培养的人内皮细胞的前列环素和内皮素-1 的产生。
DOI：
10.1034/j.1600-0609.2002.01494.x
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发表时间：
2002
影响因子：
3.1
通讯作者：
Udden,MarkM
中科院分区：
文献类型：
--
作者：
Shiu,Yan-Ting;McIntire,LarryV;Udden,MarkM
Abstract:We investigated the effects of sickle erythrocytes on the production of vasotone mediators in endothelial cells (ECs) using anin vitrorecirculating flow system. Sickle erythrocytes increased the EC production of two important vasoactivators, prostacyclin and endothelin‐1, under venous wall shear stress conditions of 1 dyn cm−2. The presence of interleukin‐1β in the perfusion system, as a model for inflammatory cytokine effects, enhanced the overall amounts of released prostacyclin but did not affect the production of endothelin‐1. This study demonstrates the effects of sickle erythrocytes on the function and metabolism of ECs under vascular flow environments. The altered production of vasoactivators may contribute to the vasotone instability and vasoocclusive crises in sickle cell anemia.
