Fatigue in multiple sclerosis: Cross-sectional correlation with brain MRI findings in 71 patients
Fatigue in multiple sclerosis: Cross-sectional correlation with brain MRI findings in 71 patients
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DOI：
10.1212/wnl.53.5.1151
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发表时间：
1999-09-22
期刊：
影响因子：
9.9
通讯作者：
Kinkel, PR
中科院分区：
文献类型：
--
作者：
Bakshi, R;Miletich, RS;Kinkel, PR
疲劳是一个原因不明，但常见的和致残的症状，在MS。我们评估了71例MS患者的疲劳，并确定MS疲劳（MSF）和MS非疲劳（MSNF）组。疲劳程度与常规序列评估的局部或整体MRI斑块负荷或萎缩无关。MSF和MSNF组之间的任何MRI测量结果均无显著差异。我们认为，脑MRI疾病的地形或严重程度不能解释疲劳的MS和疲劳可能是由于机制不佳的传统MRI的特点。
Fatigue is am unexplained but common and disabling symptom in MS. We assessed fatigue in 71 patients with MS and identified MS-fatigue (MSF) and MS-nonfatigue (MSNF) groups. Fatigue severity did not correlate with regional or global MRI plaque load or atrophy assessed by conventional sequences. No significant differences were noted in any MRI measures between MSF and MSNF groups. We suggest that brain MRI disease topography or severity does not explain fatigue in MS and that fatigue is likely due to mechanisms poorly characterized by conventional MRI.