Differences in effects of predictable and unpredictable footshock on fentanyl self-administration in rats
Differences in effects of predictable and unpredictable footshock on fentanyl self-administration in rats
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DOI：
10.1037/1064-1297.5.2.99
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发表时间：
1997-05-01
影响因子：
2.3
通讯作者：
Grunberg, NE
中科院分区：
文献类型：
--
作者：
Klein, LC;Popke, EJ;Grunberg, NE
采用操作型条件反射研究了可预测和不可预测足底电击对12只雌性和12只雄性Wistar大鼠(褐家鼠)口服芬太尼(50µg/ml)自身给药的影响。在8周内，在有和没有重复可预测或不可预测足底电击的情况下，按递增比率计划对大鼠进行药物SA测试。雌性大鼠比雄性大鼠摄入更多的芬太尼。雄性大鼠在纳洛酮刺激后表现出更大的戒断行为。与不可预测的足部电击相比，反复暴露(即慢性应激)的可预见性足部电击伴随更多的芬太尼SA，特别是对雌性大鼠。皮质酮水平与芬太尼SA呈正相关。应激源的可预测性对芬太尼SA的维持也比对芬太尼SA复发的影响更大。结果表明，性别在大鼠吸毒行为中起着重要作用。
An operant conditioning paradigm was used to examine effects of predictable and unpredictable footshock on oral fentanyl (50 mu g/ml) self-administration (SA) in 12 female and 12 male Wistar rats (Rattus norvegicus). Rats were tested for drug SA under a progressive ratio schedule with and without repeated predictable or unpredictable footshock over 8 weeks. Female rats consumed greater amounts of fentanyl than did male rats. Male rats exhibited greater withdrawal behaviors following naloxone challenge. Predictable footshock with repeated exposure (i.e., chronic stress) was accompanied by greater fentanyl SA than was unpredictable footshock, particularly for female rats. Corticosterone levels were positively correlated with fentanyl SA. Predictability of the stressor also had a greater effect on maintenance of fentanyl SA than it did on relapse to fentanyl SA. Results suggest that sex plays an important role in drug-taking behavior by rats.