Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- mice.
Sensitivity to delta9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2 -/- mice.
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DOI：
10.1097/fbp.0b013e328308f1e6
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发表时间：
2008-07
影响因子：
1.6
通讯作者：
Razdan RK
中科院分区：
文献类型：
--
作者：
Breivogel CS;Lambert JM;Gerfin S;Huffman JW;Razdan RK
Little is known about the roles of beta-arrestins in the regulation of brain CB1 cannabinoid receptors. The present study investigated the role of beta-arrestin2 in cannabinoid behavioral effects using beta-arrestin2-/- mice and their wild-type counterparts. A variety of cannabinoid ligands from different chemical classes that exhibit a variety of efficacies for activation of CB1 receptors were investigated, including Δ9-tetrahydrocannabinol (THC), CP55940, methanandamide, JWH-073 and O-1812. THC produced both greater antinociception and greater decreases in body temperature in beta-arrestin2-/- compared to beta-arrestin2+/+ mice. However, there were no significant differences in either assay for the other CB1 agonists. Antagonist radioligand binding indicated no difference in the density of cannabinoid CB1 receptors in the cerebellum, cortex or hippocampus of beta-arrestin2+/+ and -/- mice. These data demonstrate that beta-arrestin2 may regulate cannabinoid CB1 receptor sensitivity in an agonist-specific manner.
