Iterative Role of Notch Signaling in Spinal Motor Neuron Diversification.
Iterative Role of Notch Signaling in Spinal Motor Neuron Diversification.
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DOI：
10.1016/j.celrep.2016.06.067
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发表时间：
2016-07-26
期刊：
影响因子：
8.8
通讯作者：
Wichterle H
中科院分区：
文献类型：
--
作者：
Tan GC;Mazzoni EO;Wichterle H
The motor neuron progenitor domain in the ventral spinal cord gives rise to multiple subtypes of motor neurons and glial cells. Here we examined whether progenitors found in this domain are multipotent and what signals contribute to their cell type-specific differentiation. Using an in vitro neural differentiation model, we demonstrate that motor neuron progenitor differentiation is iteratively controlled by Notch signaling. First, Notch controls the timing of motor neuron genesis by repressing Neurogenin 2 (Ngn2) and maintaining Olig2-positive progenitors in a proliferative state. Second, in an Ngn2-independent manner, Notch contributes to the specification of median vs. hypaxial motor column identity and lateral vs. medial divisional identity of limb innervating motor neurons. Thus, motor neuron progenitors are multipotent and their diversification is controlled by Notch signaling that iteratively increases cellular diversity arising from a single neural progenitor domain.
