Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice
Aggravated experimental autoimmune encephalomyelitis in IL-15 knockout mice
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DOI：
10.1016/j.expneurol.2009.12.034
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发表时间：
2010-04-01
影响因子：
5.3
通讯作者：
Nieto-Sampedro, Manuel
中科院分区：
文献类型：
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作者：
Gomez-Nicola, Diego;Spagnolo, Alessandra;Nieto-Sampedro, Manuel
IL-15 最初被确定为 T 增殖细胞因子，与 IL-2 具有多种结构和生物学相似性，并且与许多自身免疫性疾病有关。由于关于 IL-15 在 MS 发病机制中的作用的信息很少，我们研究了 IL-15 的缺失如何影响实验性自身免疫性脑脊髓炎的发展，这是一种 MS 小鼠模型。用 MOG(35-55) 免疫 IL-15(-/-) 和 C57BL/6 小鼠后，我们观察到 IL-15 敲除小鼠比野生型组有更严重的神经损伤。 IL-15(-/-)小鼠疾病严重程度的增加与脊髓脱髓鞘程度的增加有关。免疫细胞浸润和炎症增加这些事件可能与IL-15KO小鼠较高的CD4/CD8比值和几乎不存在的NK细胞活性、先天性免疫特征有关。我们发现 fractalkine 受体 CX3CR1 在 IL-15(-/-) 小鼠的脊髓中过度表达。主要集中于浸润性 CD8(+) T 细胞 这些发现如何导致 IL-15 KO 小鼠 EAE 发展加剧仍不清楚，需要进一步研究 (C) 2010 Elsevier Inc 保留所有权利
IL-15 initially identified as a T proliferating cytokine has several structural and biological similarities with IL-2 and has been associated with a number of autoimmune diseases. Because of the scat-city of information available on the role of IL-15 in MS pathogenesis, we have investigated how the absence of IL-15 affected the development of experimental autoimmune encephalomyelitis, a mouse model of MS Following immunization of IL-15(-/-) and C57BL/6 mice with MOG(35-55), we observed a more severe neurological impairment in the IL-15 knockout mice than in the wild-type group. The enhanced disease severity in IL-15(-/-) mice was associated with greater demyelination in the spinal cord. increased immune cell infiltration and inflammation These events maybe related to the higher CD4/CD8 ratio and the almost absent NK cell activity, congenital immune features of IL-15KO mice Moreover. we found that the fractalkine receptor CX3CR1 was overexpressed in the spinal cord of IL-15(-/-) mice. mainly localized on infiltrating CD8(+) T cells How these findings are contributing to the aggravated EAE development in IL-15 KO mice remain unclear and need to be further investigated (C) 2010 Elsevier Inc All rights reserved