[Meta-analysis of vitamin C, vitamin E and β-carotene levels in the plasma of Alzheimer's disease patients].
[Meta-analysis of vitamin C, vitamin E and β-carotene levels in the plasma of Alzheimer's disease patients].
复制标题
DOI：
--
复制
发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
R. Dong;Qian Yang;Yusen Zhang;Jing Li;Luping Zhang;Haifeng Zhao
中科院分区：
文献类型：
--
作者：
R. Dong;Qian Yang;Yusen Zhang;Jing Li;Luping Zhang;Haifeng Zhao
OBJECTIVE To systematically evaluate the levels of vitamin C, vitamin E and β-carotene in the plasma of Alzheimer's disease( AD) patients. METHODS In this study, literature of the levels of vitamin C, vitamin E and β-carotene in the plasma of AD patients were collected by retrieving the database of Pub Med, Science Direct, CNKI and Wan Fang( from they were built to July 2017). RESULTS Meta-analysis result showed that, compared with the control group, the level of vitamin E in the plasma of AD patients declined significantly( SMD =-1. 49 μmol/L, 95% CI-2. 08--0. 89 μmol/L, P <0. 001). However, no differences were determined in the levels of the plasma vitamin C and β-carotene between the two groups( vitamin C: SMD =-1. 43 μmol/L, 95% CI-3. 05-0. 19 μmol/L, P = 0. 083; β-carotene: SMD =-0. 61 μmol/L, 95% CI-1. 40-0. 18 μmol/L, P = 0. 131). CONCLUSION Increasing vitamin E level in the plasma through vitamin E riched diet may be useful to prevent AD. However it is not yet believed the benefical role on AD to increase vitamin C and β-carotene.
