Analysis of the clinical features of early Parkinson's disease with comparatively integrated intestinal function
Analysis of the clinical features of early Parkinson's disease with comparatively integrated intestinal function
复制标题
肠道功能较为完整的早期帕金森病临床特征分析
DOI：
10.1007/s10072-018-3502-3
复制
发表时间：
2018-11-01
影响因子：
3.3
通讯作者：
Cheng, Oumei
中科院分区：
文献类型：
--
作者：
Guan, Xiaoxue;Wang, Yuchan;Cheng, Oumei
Objective Constipation is among the most frequently delineated nonmotor symptoms (NMS) with a high occurrence in Parkinson's disease (PD). The purpose of our study was to investigate whether PD with comparatively integrated intestinal function (without constipation) in the early stage had different clinical features compared to constipated PD.Method We conducted a study of 105 consecutive de novo as well as early treated (treated for shorter than 3 months), aged 50 years or older outpatients. Subjects were administered motor and nonmotor questionnaires as well as constipation associated examinations. Then, we explored the distinctive features of nonconstipated contrasted to constipated PD by using univariate, multiple regression analysis and correlation analysis.Results Nonconstipated PD tended to have fewer motor deficits, as well as lower Hoehn and Yahr (H&Y) stage and they mainly presented as tremor-dominant (TD), while constipated group had a higher occurrence of posture instability and gait difficulty (PIGD); nonconstipated patients were inclined to live in urban area, the NMSloads and prevalence of NMS were lower compared to constipated ones. Correlation analysis found a discord between NMSloads and disease severity based on H&Y stage and motor scores in nonconstipated PD.Conclusions These results suggest that PD without constipation in early stage may represent a unique clinical phenotype, which may be more benign than PD with constipation.
