Molecular mechanisms of Dicer: endonuclease and enzymatic activity.
Molecular mechanisms of Dicer: endonuclease and enzymatic activity.
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DOI：
10.1042/bcj20160759
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发表时间：
2017-05-04
期刊：
影响因子：
--
通讯作者：
Rossi JJ
中科院分区：
文献类型：
--
作者：
Song MS;Rossi JJ
Dester酶最为人所知的是它在小RNA途径中作为核内切酶的作用。在这一规范作用中，DICER是microRNA和小干扰RNA以及越来越多来自各种来源的额外小RNA的生物发生的关键调节因子。新出现的证据表明，DICER的内切酶作用不仅限于小RNA的产生，它还参与处理额外的内源和外源底物，并越来越多地参与调节其内切酶功能之外的各种其他细胞过程。这篇综述将描述DICER的典型功能和新发现的功能。
The enzyme Dicer is best known for its role as a riboendonuclease in the small RNA pathway. In this canonical role, Dicer is a critical regulator of the biogenesis of microRNA and small interfering RNA, as well as a growing number of additional small RNAs derived from various sources. Emerging evidence demonstrates that Dicer's endonuclease role extends beyond the generation of small RNAs; it is also involved in processing additional endogenous and exogenous substrates, and is becoming increasingly implicated in regulating a variety of other cellular processes, outside of its endonuclease function. This review will describe the canonical and newly identified functions of Dicer.