Inflammation and Disease Activity are Associated with High Circulating Cardiac Markers in Rheumatoid Arthritis Independently of Traditional Cardiovascular Risk Factors
Inflammation and Disease Activity are Associated with High Circulating Cardiac Markers in Rheumatoid Arthritis Independently of Traditional Cardiovascular Risk Factors
复制标题
DOI：
10.3899/jrheum.130713
复制
发表时间：
2014-02-01
影响因子：
3.9
通讯作者：
Allanore, Yannick
中科院分区：
文献类型：
--
作者：
Avouac, Jerome;Meune, Christophe;Allanore, Yannick
Objective.测定类风湿关节炎（RA）患者血清高敏心肌肌钙蛋白（HS-cTnT）和N末端脑钠肽前体（NT-proBNP）浓度，并分析其相关性。连续检测RA患者的血浆HS-cTnT和NT-proBNP浓度，并与年龄和性别匹配的健康对照组进行比较。我们纳入了236例无关的RA患者（192例女性，57 ± 13岁）和213例对照组（170例女性，55 ± 15岁）。71例RA患者无心血管（CV）危险因素。RA患者总队列的HS-cTnT和NT-proBNP浓度显著高于（分别为p = 0.03和p < 0.0001）和无CV风险因素的亚组（p = 0.02和p 5.1（OR 11.8; 95% CI 1.6-35.5）和体重指数> 30 kg/m2（OR 2.7; 95% CI 1.3-5.5）。RA患者的HS-cTnT和NTproBNP升高，与CV风险因素无关。HS-cTnT、NT-proBNP和CRP之间的相关性以及HS-cTnT与疾病活动性之间的相关性支持心肌损伤/功能障碍与炎症之间的联系。
Objective. To measure concentration S of high-sensitivity cardiac troponin (HS-cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with rheumatoid arthritis (RA) and to examine correlates.Methods. The plasma concentrations of HS-cTnT and NT-proBNP were measured in consecutive patients with RA and compared to values obtained from age-matched and sex-matched healthy controls.Results. We included 236 unrelated patients with RA (192 females, 57 +/- 13 yrs) and 213 controls (170 females, 55 +/- 15 yrs). Seventy-one patients with RA were free of cardiovascular (CV) risk factors. HS-cTnT and NT-proBNP concentrations were significantly higher in the total cohort of patients with RA (p = 0.03 and p < 0.0001, respectively) and in the subgroup free of CV risk factors (p = 0.02 and p 5.1 (OR 11.8; 95% CI 1.6-35.5) and a body mass index > 30 kg/m(2) (OR 2.7; 95% CI 1.3-5.5).Conclusion. HS-cTnT and NTproBNP are increased in patients with RA, independent of CV risk factors. The association between HS-cTnT, NT-proBNP, and CRP, together with the correlation between HS-cTnT and disease activity, support the link between myocardial injury/dysfunction and inflammation.