Correlates of insulin clearance in apparently healthy non-obese Japanese men.
Correlates of insulin clearance in apparently healthy non-obese Japanese men.
复制标题
DOI：
10.1038/s41598-017-01469-x
复制
发表时间：
2017-05-03
影响因子：
4.6
通讯作者：
Watada H
中科院分区：
文献类型：
--
作者：
Kaga H;Tamura Y;Takeno K;Kakehi S;Funayama T;Furukawa Y;Nishitani-Yokoyama M;Shimada K;Daida H;Aoki S;Giacca A;Kanazawa A;Kawamori R;Watada H
在肥胖受试者中观察到的高胰岛素血症至少部分是由胰岛素代谢清除率（MCRI）低引起的。然而，非肥胖受试者 MCRI 的决定因素尚不完全清楚。为了调查健康非肥胖男性 (BMI <25kg/m2) MCRI 的相关性，我们研究了 49 名没有心脏代谢危险因素的非肥胖日本男性。使用两步高胰岛素正常血糖钳夹，我们评估了 MCRI 和胰岛素敏感性。我们还计算了钳夹期间的葡萄糖消失率（Rd），并且在第二步将肌肉胰岛素敏感性定义为Rd/稳态血清胰岛素（SSSI）。根据 MCRI 中值，将受试者分为低 MCRI 组和高 MCRI 组。低 MCRI 组的受试者肌肉胰岛素敏感性显着受损，尽管两组之间的 Rd 水平相当，这可能是由于低 MCRI 组的 SSSI 升高所致。低 MCRI 组的受试者具有较高的全身脂肪含量和较低的 VO2peak，并且心脏代谢危险因素没有恶化。我们的结果表明，面对肥胖增加和健康水平较低导致的肌肉胰岛素敏感性轻微受损，低 MCRI 可能是维持葡萄糖摄取和代谢状态的早期改变。
Hyperinsulinemia observed in obese subject is caused at least in part by low metabolic clearance rate of insulin (MCRI). However, the determinants of MCRI in non-obese subjects are not fully understood. To investigate the correlates of MCRI in healthy non-obese men (BMI <25 kg/m2), we studied 49 non-obese Japanese men free of cardiometabolic risk factors. Using a 2-step hyperinsulinemic euglycemic clamp, we evaluated MCRI and insulin sensitivity. We also calculated the rate of glucose disappearance (Rd) during the clamp and muscle insulin sensitivity was defined as Rd/steady state serum insulin (SSSI) at the second step. Based on the median value of MCRI, the subjects were divided into the low- and high-MCRI groups. Subjects of the low-MCRI group had significant impairment of muscle insulin sensitivity, although Rd levels were comparable between the two groups, probably due to elevated SSSI in the low-MCRI group. Subjects of the low-MCRI group had higher total body fat content and lower VO2peak and showed no deterioration of cardiometabolic risk factors. Our results suggest that low MCRI may be early change to maintain glucose uptake and metabolic status in the face of slight impairment of muscle insulin sensitivity caused by increased adiposity and lower fitness level.