MYOCARDIAL FIBROSIS AND STIFFNESS WITH HYPERTROPHY AND HEART-FAILURE IN THE SPONTANEOUSLY HYPERTENSIVE RAT
MYOCARDIAL FIBROSIS AND STIFFNESS WITH HYPERTROPHY AND HEART-FAILURE IN THE SPONTANEOUSLY HYPERTENSIVE RAT
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DOI：
10.1161/01.cir.91.1.161
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发表时间：
1995-01-01
期刊：
影响因子：
37.8
通讯作者：
BING, OHL
中科院分区：
文献类型：
--
作者：
CONRAD, CH;BROOKS, WW;BING, OHL
背景纤维化常与心脏肥大和心力衰竭有关，但结缔组织反应与心功能受损的关系尚不清楚。我们检测了自发性高血压大鼠（SHR）的被动心肌僵硬度、主动收缩功能和纤维化，方法和结果我们研究了正常血压Wistar-Kyoto（WKY）大鼠和自发性高血压大鼠（SHR）左心室乳头肌的被动和主动力学特性。在12个月和20到23个月的时候。20至23个月大的15只SHR中有7只的结果与心力衰竭（SHR-F）一致。与来自WKY大鼠和非衰竭SHR（SHR-NF）的制备物相比，来自SHR-F组的乳头肌表现出增加的被动刚度（中央段指数刚度常数，k（cs）：SHR-F 95.6+/-19.8，SHR-NF 42.1+/-9.7，WKY大鼠39.5+/-9.5（平均值+/-SD）; SHR-F P
Background Fibrosis is commonly found in association with cardiac hypertrophy and failure, but the relation of the connective tissue response to the development of impaired cardiac function remains unclear. We examined passive myocardial stiffness, active contractile function, and fibrosis in the spontaneously hypertensive rat (SHR), a model of chronic pressure overload in which impaired cardiac function follows a long period of stable hypertrophy.Methods and Results We studied the passive and active mechanical properties of left ventricular (LV) papillary muscles isolated from normotensive Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) at the ages of 12 months and 20 to 23 months. Seven of 15 SHR between 20 and 23 months of age had findings consistent with heart failure (SHR-F). In comparison to preparations from WKY rats and nonfailing SHR (SHR-NF), papillary muscles from the SHR-F group demonstrated increased passive stiffness (central segment exponential stiffness constant, k(cs): SHR-F 95.6+/-19.8, SHR-NF 42.1+/-9.7, WKY rats 39.5+/-9.5 (mean+/-SD); SHR-F P