Vasopressin in the lateral septum regulates pair bond formation in male prairie voles (Microtus ochrogaster)
Vasopressin in the lateral septum regulates pair bond formation in male prairie voles (Microtus ochrogaster)
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DOI：
10.1037//0735-7044.115.4.910
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发表时间：
2001-08-01
影响因子：
1.9
通讯作者：
Wang, ZX
中科院分区：
文献类型：
--
作者：
Liu, Y;Curtis, JT;Wang, ZX
雄性草原田鼠(Microtus Ochrogaster)在交配后与雌性伴侣形成一对纽带，这一行为受到神经肽血管加压素(AVP)的调节。作者报道，外侧隔中的AVP对成对键的形成是重要的。在外侧隔区注射AVP VLA受体拮抗剂可阻断交配诱导的配对结合，而在没有交配的情况下给予AVP则可诱导这种行为。此外。在外侧隔区注射催产素(OT)受体拮抗剂也可阻断交配或AVP引起的配对结合，提示OT受体阻断可能干扰了AVP对行为的调节。综上所述，这些数据提供了证据表明，外侧隔中的AVP调节着雄性草原选票中对键的形成，这一过程需要获得AVP和OT受体。
Male prairie votes (Microtus ochrogaster) form a pair bond with a female partner after mating, and this behavior is regulated by the neuropeptide vasopressin (AVP). The authors report that AVP in the lateral septum is important for pair bond formation. Administration of an AVP Vla receptor antagonist in the lateral septum blocked mating-induced pair bonding, whereas administration of AVP induced this behavior in the absence of mating. In addition. administration of an oxytocin (OT) receptor antagonist in the lateral septum also blocked pair bond formation induced by either mating or AVP administration, suggesting that the OT receptor blockade may have interfered with the AVP regulation of behavior. Together, these data provide evidence suggesting that AVP in the lateral septum regulates pair bond formation in male prairie votes and that this process requires access to both AVP and OT receptors.