Projection-data based temporal maximum attenuation computed tomography: determination of internal target volume for lung cancer against intra-fraction motion
Projection-data based temporal maximum attenuation computed tomography: determination of internal target volume for lung cancer against intra-fraction motion
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DOI：
10.1088/0031-9155/52/4/011
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发表时间：
2007-02-21
影响因子：
3.5
通讯作者：
Endo, Masahiro
中科院分区：
文献类型：
--
作者：
Mori, Shinichiro;Kanematsu, Nobuyuki;Endo, Masahiro
内靶体积（ITV）的概念在肺的放射治疗中非常重要，肺是一个受器官运动阻碍的器官。到目前为止，已经公布了获得ITV的不同方法，因此可以使用。为了定义ITV，我们开发了一种新的方法，通过调整时间滤波器的四维CT扫描技术（4DCT），这是投影数据处理（4D投影数据最大衰减（4DIM）），并比较它与重建图像处理（4D图像最大强度投影（4DIM））使用体模和临床评价。4DIM和4DIM可以很容易地捕获准确的最大强度体积（MIV），即肿瘤包围体积。尽管4DIM将CT数量增加到4DIM的1.8倍，但4DIM通过重建算法为MIV提供了原始肿瘤CT数量。在具有肺纤维化蜂窝的患者中，4DIM的MIV在头尾方向上比电影成像的MIV大0.7cm。因此，4000提供了与患者特征和重建条件无关的准确MIV。这些结果表明，4S在确定ITV在放射治疗中的有用性。
The concept of internal target volume (ITV) is highly significant in radiotherapy for the lung, an organ which is hampered by organ motion. To date, different methods to obtain the ITV have been published and are therefore available. To define ITV, we developed a new method by adapting a time filter to the four-dimensional CT scan technique (4DCT) which is projection-data processing (4D projection data maximum attenuation (4DPM)), and compared it with reconstructed image processing (4D image maximum intensity projection (4DIM)) using a phantom and clinical evaluations. 4DIM and 4DPM captured accurate maximum intensity volume (MIV), that is tumour encompassing volume, easily. Although 4DIM increased the CT number 1.8 times higher than 4DPM, 4DPM provided the original tumour CT number for MIV via a reconstruction algorithm. In the patient with lung fibrosis honeycomb, the MIV with 4DIM is 0.7 cm larger than that for cine imaging in the cranio-caudal direction. 4DPM therefore provided an accurate MIV independent of patient characteristics and reconstruction conditions. These findings indicate the usefulness of 4DPM in determining ITV in radiotherapy.