Computed tomographic findings of ceroid lipofuscinosis in a dog.
Computed tomographic findings of ceroid lipofuscinosis in a dog.
复制标题
狗蜡样质脂褐质沉着症的计算机断层扫描结果。
DOI：
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
R. Storts
中科院分区：
文献类型：
--
作者：
J. Franks;Curtis Wells Dewey;M. Walker;R. Storts
一个两岁零七个月大，阉割的雄性边境牧羊犬被提出了两个月的历史进行性神经系统体征，包括失明，共济失调，痴呆和部分性癫痫发作。全血细胞计数、血清生化特征、尿液分析、胸部X线片和脑脊液分析均在参考范围内。脑部计算机断层扫描（CT）显示脑室扩张和大脑皮质萎缩。怀疑存在中枢神经系统（CNS）贮积病，由于预后不良，对犬实施安乐死。光学和电子显微镜检查显示CNS神经元、周围神经系统神经节和几种非神经组织中的神经元变性伴色素蓄积。蜡样脂褐质沉积症的诊断是基于显微镜和超微结构病变检测。这是第二次报告的CT表现在犬临床病人蜡样脂褐质沉积症。
A two-year and seven-month-old, castrated male border collie was presented for a two-month history of progressive neurological signs including blindness, ataxia, dementia, and partial seizures. A complete blood count, serum biochemical profile, urinalysis, thoracic radiographs, and cerebrospinal fluid analysis were within reference ranges. Computed tomography (CT) of the brain showed dilatation of the ventricles and atrophy of the cerebral cortex. A central nervous system (CNS) storage disease was suspected, and the dog was euthanized due to a poor prognosis. Light and electron microscopic examination revealed neuronal degeneration with pigment accumulation in neurons of the CNS, in ganglia of the peripheral nervous system, and in several non-nervous tissues. Ceroid lipofuscinosis was diagnosed based on the microscopic and ultrastructural lesions detected. This is the second report of CT findings in a canine clinical patient with ceroid lipofuscinosis.
神经元蜡质脂褐质沉积症婴儿晚期形式的新亚型。
影响因子：
1.4
作者：
Wisniewski,KE;Kida,E;Connell,F;Elleder,M;Eviatar,L;Konkol,RJ
通讯作者：
Konkol,RJ