Separating population structure from population history: a cladistic analysis of the geographical distribution of mitochondrial DNA haplotypes in the tiger salamander, Ambystoma tigrinum.
Separating population structure from population history: a cladistic analysis of the geographical distribution of mitochondrial DNA haplotypes in the tiger salamander, Ambystoma tigrinum.
复制标题
将种群结构与种群历史分离：对虎蝾螈 Ambystoma tigrinum 线粒体 DNA 单倍型地理分布的分支分析。
DOI：
10.1093/genetics/140.2.767
复制
发表时间：
1995
期刊：
影响因子：
3.3
通讯作者：
Phillips,CA
中科院分区：
文献类型：
--
作者：
Templeton,AR;Routman,E;Phillips,CA
等位基因或单倍型与地理位置的非随机关联可能来自限制性基因流动、历史事件（片段化、分布区扩张、殖民化）或这些因素的任何混合。在本文中，我们展示了如何嵌套的分支分析的地理距离可以用来检验零假设没有地理关联的单倍型，检验的假设，即显着的协会是由于限制基因流，并确定模式的显着关联是由于历史事件。在这最后一种情况下，标准是区分连续的范围扩张，长距离殖民，和人口碎片化。作出这些区分的能力关键取决于适当的地理抽样设计。这些点说明了一个工作的例子：线粒体DNA单倍型在蝾螈Ambystoma tigrinum。对于这个例子，先验信息存在的限制基因流和可能的历史事件，嵌套分支分析是完全一致的，与此先验信息。这种一致性建立了这种嵌套分支方法的可行性，但未来的工作将是必要的，以证明鲁棒性，并探讨这种程序的权力和准确性。
Nonrandom associations of alleles or haplotypes with geographical location can arise from restricted gene flow, historical events (fragmentation, range expansion, colonization), or any mixture of these factors. In this paper, we show how a nested cladistic analysis of geographical distances can be used to test the null hypothesis of no geographical association of haplotypes, test the hypothesis that significant associations are due to restricted gene flow, and identify patterns of significant association that are due to historical events. In this last case, criteria are given to discriminate among contiguous range expansion, long-distance colonization, and population fragmentation. The ability to make these discriminations depends critically upon an adequate geographical sampling design. These points are illustrated with a worked example: mitochondrial DNA haplotypes in the salamander Ambystoma tigrinum. For this example, prior information exists about restricted gene flow and likely historical events, and the nested cladistic analyses were completely concordant with this prior information. This concordance establishes the plausibility of this nested cladistic approach, but much future work will be necessary to demonstrate robustness and to explore the power and accuracy of this procedure.