Implication of two different regeneration systems in limb regeneration.
Implication of two different regeneration systems in limb regeneration.
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DOI：
10.1002/reg2.16
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发表时间：
2014-06
期刊：
影响因子：
--
通讯作者：
Satoh A
中科院分区：
文献类型：
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作者：
Makanae A;Mitogawa K;Satoh A
肢体再生是有尾目两栖动物器官再生的一种典型现象，如美西螈。一个截肢的肢体开始从剩余的残肢（近端）到失去的指尖（远端）再生。在本例中，近端-远端（PD）重组发生在再生组织中，称为芽基。诱导芽基如何识别其位置并恢复缺失部分的精确复制一直是个谜。近年来，一种新的实验系统被称为副肢模型（ALM）已经建立。获得的ALM表型要求重新考虑重组PD位置值。基于ALM表型，可以合理地假设位置值的重组具有一定的不连续性，并且两个不同的再生系统协作重组PD轴以恢复原始结构。本文综述了PD轴重建的研究进展，重点是肢体再生。在蝾螈和非洲爪蟾的ALM研究的知识提供了一个新的概念PD轴重组肢体再生。
Limb regeneration is a representative phenomenon of organ regeneration in urodele amphibians, such as an axolotl. An amputated limb starts regenerating from a remaining stump (proximal) to lost finger tips (distal). In the present case, proximal−distal (PD) reorganization takes place in a regenerating tissue, called a blastema. It has been a mystery how an induced blastema recognizes its position and restores an exact replica of missing parts. Recently, a new experimental system called the accessory limb model (ALM) has been established. The gained ALM phenotypes are demanding to reconsider the reorganization PD positional values. Based on the ALM phenotype, it is reasonable to hypothesize that reorganization of positional values has a certain discontinuity and that two different regeneration systems cooperatively reorganize the PD axis to restore an original structure. In this review, PD axis reestablishments are focused on limb regeneration. Knowledge from ALM studies in axolotls and Xenopus is providing a novel concept of PD axis reorganization in limb regeneration.