Controlled Au-Polymer Nanostructures for Multiphoton Imaging, Prodrug Delivery, and Chemo-Photothermal Therapy Platforms
Controlled Au-Polymer Nanostructures for Multiphoton Imaging, Prodrug Delivery, and Chemo-Photothermal Therapy Platforms
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DOI：
10.1021/acsami.5b07110
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发表时间：
2015-11-18
影响因子：
9.5
通讯作者：
Liu, Tzu-Ming
中科院分区：
文献类型：
--
作者：
Huang, Chih-Chia;Liu, Tzu-Ming
我们成功地引入了质子诱导的HAuCl 4和聚（苯乙烯-马来酸）钠盐（PSMA）的可控反应来制备三角形和多核Au@聚合物纳米颗粒（NPs）。核内的粒子间相互作用在近红外波长处产生吸收带。所得到的Au-聚合物纳米结构的近红外光学性质在生理环境中是高度稳定的，其通过中等连续波808 nm激光提供了强的光热转换，并表现出用于使用1230 nm光激发（飞秒激光）成像的多光子荧光。暴露在聚合物壳上的羧酸酯基团使得Au多核@聚合物NP的表面结构直接缀合基于Pt（II）/Pt（IV）的药物，其具有在短时间内消除立即毒性并在3天后产生抗癌效果。化疗-光热疗法的协同效应显示中度热疗辅助（
We have successfully introduced a proton-induced controlled reaction of HAuCl4 and poly(styrene-alt-maleic acid) (PSMA) sodium salt to prepare triangular and multicore Au@polymer nanoparticles (NPs). The interparticle interactions in the core gave rise to an absorption band at the near-infrared wavelength. The near-infrared optical properties of the resulting Au-polymer nanostructures are highly stable in a physiological environment, which offered strong photo-to-thermal conversion by a moderate continuous-wave 808 nm laser and exhibited multiphoton fluorescence for imaging using a 1230 nm light excitation (femtosecond laser). Exposure of the carboxylate groups at the polymer shell made the surface structure of the Au multicore @polymer NPs directly conjugate Pt(II)-/Pt(IV)-based drugs, which possessed the elimination of the immediate toxicity over the short time and resulted in an anticancer effect after 3 days. A synergistic effect of the chemo-photothermal therapy showed a moderate hyperthermia assistance (