The brain reserve hypothesis, brain atrophy and aging
The brain reserve hypothesis, brain atrophy and aging
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DOI：
10.1159/000096482
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发表时间：
2007-01-01
期刊：
影响因子：
3.5
通讯作者：
Sachdev, Perminder
中科院分区：
文献类型：
--
作者：
Christensen, Helen;Anstey, Kaarin J.;Sachdev, Perminder
背景资料：研究人员使用脑储备的概念来解释病理性脑损伤与认知和功能表现之间的分离。各种各样的脑储备假说存在，不同的经验策略已被用来调查这些变量。目的：该研究调查了（i）脑负荷测量（萎缩，白色高信号（WMH））和储备测量（教育，创造力和智力）之间的关系;（ii）认知下降和储备之间的关系;（iii）储备测量是否介导萎缩对估计认知变化的影响，以及（iv）脑风险因素，教育和萎缩之间的关联。方法：对446名60-64岁的个体进行横断面研究，这些个体接受MRI扫描作为大型流行病学研究的一部分。测量了受教育程度、智力、创造力、认知速度、脑容量、WMH、估计的早期认知能力下降和脑萎缩。结果：在估计的认知下降和脑负荷（萎缩，WMH）之间没有发现关联。在受教育程度较低的人群中，脑损伤的危险因素与脑萎缩程度无关。无论是教育，还是包括智力或创造力在内的任何其他措施，都不能为高水平脑萎缩的个体的认知能力下降提供缓冲。结论：脑储备假说的支持率很低。版权所有（c）2007 S. Karger AG，巴塞尔。
Background: Researchers have used the concept of brain reserve to explain the dissociation between pathological brain damage and cognitive and functional performance. A variety of brain reserve hypotheses exist, and different empirical strategies have been employed to investigate these variants. Objective: The study investigates (i) the relationship between measures of brain burden (atrophy, white matter hyperintensities (WMH)) and measures of reserve (education, creativity, and intelligence); (ii) the relationship between cognitive decline and reserve; (iii) whether measures of reserve mediate the effect of atrophy on estimated cognitive change, and (iv) the association between brain risk factors, education and atrophy. Methods: A cross-sectional study of a sample of 446 individuals 60-64 years of age who underwent MRI scans as part of a large epidemiological study. Measures were taken of education, intelligence, creativity, cognitive speed, brain volume, WMH, estimated cognitive decline from earlier in life and brain atrophy. Results: No association was found between estimated cognitive decline and brain burden ( atrophy, WMH). Risk factors for brain insult were not associated with greater brain atrophy in the less well educated. Neither education, nor any other measure including intelligence or creativity, provided a buffer for cognitive decline in individuals with high levels of brain atrophy. Conclusion: Little support was found for the brain reserve hypothesis. Copyright (c) 2007 S. Karger AG, Basel.