LY393615, a novel neuronal Ca2+ and Na+ channel blocker with neuroprotective effects in models of in vitro and in vivo cerebral ischemia
LY393615, a novel neuronal Ca2+ and Na+ channel blocker with neuroprotective effects in models of in vitro and in vivo cerebral ischemia
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DOI：
10.1016/s0006-8993(00)03043-2
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发表时间：
2001-01-05
期刊：
影响因子：
2.9
通讯作者：
Boot, JR
中科院分区：
文献类型：
--
作者：
O'Neill, MJ;Hicks, CA;Boot, JR
在本研究中，我们已经检查了一种新的钙通道阻滞剂，LY 393615（（N-丁基-[5，5-双-（4-氟苯基）四氢呋喃-2-基]甲胺盐酸盐，NCC 1048）在体外缺氧低血糖模型和沙土鼠模型的整体和两个大鼠模型的局灶性脑缺血在体内的影响。结果表明，当剂量为10、12.5（P）时，LY 393615可保护脑切片免受缺氧-低血糖损伤，并且还可显着保护沙鼠全脑缺血中缺血诱导的海马损伤
In the present studies we have examined the effects of a new calcium channel blocker, LY393615 ((N-Butyl-[5,5-bis-(4-fluorophenyl)tetrahydrofuran-2-yl]methylamine hydrochloride, NCC1048) in a model of hypoxia-hypoglycaemia in vitro and in a gerbil model of global and in two rat models of focal cerebral ischaemia in vivo. Results indicated that LY393615 protected against hypoxia-hypoglycaemic insults in brain slices and also provided significant protection against ischaemia-induced hippocampal damage in gerbil global cerebral ischaemia when dosed at 10, 12.5 (P