Screening for HIV-related neurocognitive impairment in clinical practice: Challenges and opportunities
Screening for HIV-related neurocognitive impairment in clinical practice: Challenges and opportunities
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DOI：
10.1080/09540121.2013.819401
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发表时间：
2014-02-01
影响因子：
1.7
通讯作者：
Catalan, J.
中科院分区：
文献类型：
--
作者：
Barber, T. J.;Bradshaw, D.;Catalan, J.
随着艾滋病毒管理的日益成功，重点已从艾滋病相关并发症转移到其他慢性合并症。对于hiv相关的认知问题，真正的发病机制和流行病学仍不清楚。本文不是一个系统的回顾，而是提出了我们在建立自己的临床服务时面临的挑战和机遇。论文使用Pubmed和术语筛选，HIV和神经认知进行鉴定。本文介绍了hiv相关神经认知障碍（HAND）的背景，重点介绍了hiv相关神经认知障碍（NCI），详细介绍了分类、患病率、诊断类别和诊断不确定性。筛选是讨论，包括现有的筛选工具的比较，在艾滋病毒感染患者的认知缺陷和实践效果的重要性。还讨论了正常范围和缺乏正常范围，以及对发现有缺陷的人进行潜在的调查。最后，我们讨论了目前NCI筛查在常规临床护理中的作用。
With increasingly successful management of HIV, focus has shifted away from AIDS-related complications to other chronic co-morbidities. For HIV-related cognitive problems, the true aetiopathogenesis and epidemiology remains unclear. Rather than a systematic review, this paper presents the challenges and the opportunities we faced in establishing our own clinical service. Papers were identified using Pubmed and the terms screening, HIV and neurocognitive. This article covers the background of HIV-associated neurocognitive disorders (HAND) with a focus on HIV-related neurocognitive impairment (NCI), detailing classification, prevalence, diagnostic categories and diagnostic uncertainties. Screening is discussed, including a comparison of the available screening tools for cognitive deficits in HIV-infected patients and the importance of practice effects. Discussed also are the normal ranges and the lack thereof and potential investigations for those found to have impairments. We conclude by discussing the role of NCI screening in routine clinical care at the current time.