Per- and Polyfluoroalkyl Substances (PFAS) in Breast Milk: Concerning Trends for Current-Use PFAS.
Per- and Polyfluoroalkyl Substances (PFAS) in Breast Milk: Concerning Trends for Current-Use PFAS.
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母乳中的全氟和多氟烷基物质（PFAS）：关于目前使用PFAS的趋势。
DOI：
10.1021/acs.est.0c06978
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发表时间：
2021-05
影响因子：
11.4
通讯作者：
Guomao Zheng;Erika Schreder;J. Dempsey;Nancy Uding;Valerie Chu;G. Andres;S. Sathyanarayana;Amina Salamova
中科院分区：
文献类型：
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作者：
Guomao Zheng;Erika Schreder;J. Dempsey;Nancy Uding;Valerie Chu;G. Andres;S. Sathyanarayana;Amina Salamova
这是过去15年来第一项分析美国母亲（n = 50）母乳中全氟烷基和多氟烷基物质（PFAS）的研究，我们的研究结果表明，传统和当前使用的PFAS现在都会污染母乳，暴露哺乳期婴儿。分析了母乳中的39种PFAS，包括9种短链和30种长链化合物，其中16种PFAS在4-100%的样品中检出。母乳中的∑PFAS浓度范围为52.0至1850 pg/mL，中位浓度为121 pg/mL。全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）是这些样本中含量最高的PFAS（中位数分别为30.4和13.9皮克/毫升）。在大多数样品中检测到两种短链PFAS，包括全氟正己酸（PFHxA，C6）和全氟正庚酸（PFHpA，C7），中位浓度分别为9.69和6.10 pg/mL。对1996年至2019年期间世界各地母乳全氟辛烷磺酸数据的分析表明，虽然逐步淘汰的全氟辛烷磺酸和全氟辛酸的水平一直在下降，分别减少了8.1年和17年的一半时间，但目前使用的短链全氟辛烷磺酸的检测频率一直在增加，增加了4.1年的一倍时间。
This is the first study in the last 15 years to analyze per- and polyfluoroalkyl substances (PFAS) in breast milk collected from mothers (n = 50) in the United States, and our findings indicate that both legacy and current-use PFAS now contaminate breast milk, exposing nursing infants. Breast milk was analyzed for 39 PFAS, including 9 short-chain and 30 long-chain compounds, and 16 of these PFAS were detected in 4-100% of the samples. The ∑PFAS concentration in breast milk ranged from 52.0 to 1850 pg/mL with a median concentration of 121 pg/mL. Perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) were the most abundant PFAS in these samples (medians 30.4 and 13.9 pg/mL, respectively). Two short-chain PFAS, including perfluoro-n-hexanoic acid (PFHxA, C6) and perfluoro-n-heptanoic acid (PFHpA, C7), were detected in most of the samples with median concentrations of 9.69 and 6.10 pg/mL, respectively. Analysis of the available breast milk PFAS data from around the world over the period of 1996-2019 showed that while the levels of the phased-out PFOS and PFOA have been declining with halving times of 8.1 and 17 years, respectively, the detection frequencies of current-use short-chain PFAS have been increasing with a doubling time of 4.1 years.