Six carotenoids in plasma used to assess recommended intake of fruits and vegetables in a controlled feeding study
Six carotenoids in plasma used to assess recommended intake of fruits and vegetables in a controlled feeding study
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DOI：
10.1038/sj.ejcn.1601945
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发表时间：
2004-08-01
影响因子：
4.7
通讯作者：
Drevon, CA
中科院分区：
文献类型：
--
作者：
Brevik, A;Andersen, LF;Drevon, CA
背景资料：对于被认为影响人类健康的食物的摄入量，需要客观的和普遍适用的生物标志物。目的：本喂养研究的目的是测试血浆类胡萝卜素浓度是否可以用来区分混合水果和蔬菜的推荐摄入量（每天五份）从目前全国水果蔬菜摄入量设计：选择严格的交叉设计来校正观察到的类胡萝卜素反应的个体间差异。本研究共纳入40例健康受试者。经过一周的磨合期，饮食中没有水果和蔬菜，一组每天给予两份（300 g）水果和蔬菜，而另一组每天给予五份（750 g）水果和蔬菜，持续14天。在2周洗脱期和1周导入期后，在两组之间转换方案。水果和蔬菜相结合，以匹配一个典型的挪威diet.Results：增强摄入量从两个到五个部分的混合水果和蔬菜增加α-胡萝卜素（P = 0.033）和叶黄素（P = 0.051）在交叉分析的血浆浓度。在研究的平行部分中的数据分析显示，α-胡萝卜素（P = 0.013）和β-胡萝卜素（P = 0.016）的血浆浓度的高和低摄入量之间的差异。在平行分析中，番茄红素（P = 0.057）和叶黄素（P = 0.076）的血浆浓度趋势也很明显。高与低摄入量的水果和蔬菜对β-隐黄质、玉米黄质、胆固醇和三酰甘油的血浆浓度没有影响。研究表明，血浆中α-胡萝卜素的浓度，β-的胡萝卜素和叶黄素可用于评估水果和蔬菜摄入量的变化，这些变化对应于从挪威目前的全国摄入量增加到五份水果的推荐量，赞助：挪威研究理事会、国家营养理事会、Throne Holst营养研究基金会和Freia Chokoladefabriks Medisinske Fond。
Background: There is a need for objective and universally applicable biomarkers for the intake of foods believed to affect human health.Objective: The purpose of this feeding study was to test whether plasma concentrations of carotenoids could be used to distinguish recommended consumption of mixed fruits and vegetables ( five a day) from the current national intake of fruits and vegetables ( two a day).Design: A strict crossover design was chosen to correct for observed interindividual variations in carotenoid response. A total of 40 healthy subjects were included in the study. After 1 week run-in period with no fruits and vegetables in the diet, one group was given two portions ( 300 g) of fruits and vegetables daily, while another group was given five portions (750 g) for 14 days. Following a 2 week wash-out period and 1 week run-in, the regimens were switched between the groups. Fruits and vegetables were combined to match a typical Norwegian diet.Results: Enhanced intake from two to five portions of mixed fruits and vegetables increased plasma concentrations of alpha-carotene (P = 0.033) and lutein (P = 0.051) in a crossover analysis. Analysis of data in the parallel part of the study revealed differences between the high and low intake for plasma concentrations of alpha-carotene (P = 0.013) and beta-carotene (P = 0.016). A trend was also evident for plasma concentrations of lycopene (P = 0.057) and lutein (P = 0.076) in the parallel analysis. No effect of high vs low intake of fruits and vegetables was observed for plasma concentrations of beta-cryptoxanthin, zeaxanthin, cholesterol and triacylglycerols.Conclusion: The study indicates that plasma concentration of alpha-carotene, beta-carotene and lutein may be used to assess changes of fruit and vegetable intake corresponding to an increase from the present national intake in Norway to the recommended amount of five portions of fruits and vegetables daily.Sponsorship: Norwegian Research Council, National Nutrition Council, Throne Holst Foundation for Nutrition Research and Freia Chokoladefabriks Medisinske Fond.